Cytotoxic Phenolic Constituents from the Root of Actinidia chinensis

Abstract

Twelve phenolic compounds, including four novel skeleton phenolic compounds, planchols A - D (1 - 4), together with four pairs of isomeric flavanoids (5 - 12) were isolated from the root of Actinidia chinensis Planch (Actinidiaceae). Their structures were elucidated by spectroscopic analysis and chemical evidence. The structure of 1 was further confirmed by a single-crystal X-ray diffraction determination. Moreover, it was found that 1 and 2 showed remarkable cytotoxic activity against P-388 and A-549 cell lines.

Key words

Actinidia chinensis Planch - Actinidiaceae - phenolic compounds - planchols A - D - flavanoids - cytotoxic activity

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