Towards the Syntheses of α-Trifluoromethylated Oxygenated Heterocycles and Their Precursors

Abstract

The possibilities of synthesizing various α-trifluoro­methylated oxygenated heterocycles, starting from trifluoroacetaldehyde methyl hemiacetal, through classic cyclization reactions, have been demonstrated. In this way, six-membered cyclic compounds, δ-lactones and also macrolactones, bearing a CF₃ group in a position α to the oxygen could be easily obtained through a RCM reaction. Bicyclic compounds could be also synthesized by an intramolecular Pauson-Khand reaction.

Key words

fluorine - metathesis - cyclizations - oxygenated heterocycles - trifluoroacetaldehyde

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