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Synfacts 2005(1): 0162-0162  
DOI: 10.1055/s-2005-872132
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Base-Promoted Dimerization of Terminal Epoxides

Contributor(s): Paul Knochel, Andrei Gavryushin
D. M. Hodgson*, C. D. Bray, N. D. Kindon
University of Oxford, UK
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Publication History

Publication Date:
21 September 2005 (online)

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Significance

This is a simple procedure for the preparation of not so easily available 2-ene-1,4-diols from terminal epoxides with retention of chirality. Reduction of the double bond gives synthetically important chiral saturated 1,4-diols.