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Synfacts 2005(2): 0241-0241
DOI: 10.1055/s-2005-916109
DOI: 10.1055/s-2005-916109
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Michael Reactions of β-Ketoesters and Unsaturated N-Acylthiazolidinethiones
D. A. Evans*, R. J. Thomson, F. Franco
Harvard University, cambridge, USA
Further Information
Publication History
Publication Date:
25 October 2005 (online)
Significance
The Michael reaction has remained a powerful transformation in organic chemistry. This report represents a simple direct Michael reaction of β-ketoesters to unsaturated N-acylthiazolidinethiones. The high yields and high enantioselectivity of this reaction make it an attractive method for the formation of products that can easily be converted into dihydropyrone derivatives as well as acyclic keto-esters.