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Synthesis 2006(1): 49-54
DOI: 10.1055/s-2005-918431
DOI: 10.1055/s-2005-918431
PAPER
© Georg Thieme Verlag Stuttgart · New York
Reduction of 2,5-Bis(3′-indolyl)pyrazines to 2,5-Bis(3′-indolyl)piperazines: Synthesis of Bisindolylpiperazine Marine Alkaloids Dragmacidin A, B, and C
Further Information
Received
1 May 2005
Publication Date:
25 October 2005 (online)
Publication History
Publication Date:
25 October 2005 (online)
Abstract
A concise total synthesis of the bisindole alkaloids dragmacidin A, B and C is described that centers on the preparation and reduction of 2,5-bis(3′-indolyl)pyrazines to 2,5-bis(3′-indolyl)piperazines.
Key words
total synthesis - indoles - reductions - pyrazines - piperazines
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