Synthesis of Orthogonally Protected Pyrrole Tricarboxylic Acid Derivatives: Versatile Building Blocks for Pyrrole-Containing Compounds

Carsten Schmuck; Daniel Rupprecht; Christian Urban; Nicholas Walden

doi:10.1055/s-2005-918435

PAPER

Synthesis of Orthogonally Protected Pyrrole Tricarboxylic Acid Derivatives: Versatile Building Blocks for Pyrrole-Containing Compounds

Carsten Schmuck*, Daniel Rupprecht, Christian Urban, Nicholas Walden
University of Würzburg, Institute of Organic Chemistry, Am Hubland, 97074 Würzburg, Germany
Fax: +49(931)8884625; e-Mail: schmuck@chemie.uni-wuerzburg.de;

Abstract

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Abstract

The large-scale synthesis of three new orthogonally protected pyrrole tricarboxylates 1-3 is described. Using different cleavage conditions, each of the three carboxylates can be set free selectively without affecting the others, making these pyrrole derivatives versatile synthetic building blocks for a wide range of applications in natural product or supramolecular chemistry.

Key words

pyrroles - carboxylic acids - protecting groups - transesterifications - oxidations

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References

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