Stereoselective Synthesis of 3,6-Disubstituted 1,2-Diaminocyclohexanes through Ring-Closing Metathesis of 4,5-Diamino-1,7-octadiene Derivatives

Abstract

3,6-Disubstituted 4,5-di[(S)-1-phenylethylamino]-1,7-octadienes with different configurations at the carbon stereocenters were protected as dihydrochlorides or cyclic phosphorous diamides and then converted into (1R,2R)-3,6-disubstituted 1,2-diaminocyclohexanes through ruthenium-catalyzed ring-closing metathesis and subsequent hydrogenolysis-hydrogenation steps.

Key words

catalysis - cyclization - diamines - metathesis - ruthenium

References

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