A Simple and Efficient Synthesis of Methyl 3,4-Dihydro-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide from Saccharin Sodium Salt

Abstract

A straightforward synthesis of methyl 3,4-dihydro-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide from saccharin sodium salt was achieved in five steps. Methyl 3,4-dihydro-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide found application as a precursor for the synthesis of a new class of quaternary ammonium derivatives that are potential antiosteoarthritis agents.

Key words

oxicams - quaternary ammonium - heterocycles - esters - enols

References

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Vidal, A.; Renard, P.; Madelmont, J. C.; Mounetou, E. J. Med. Chem. submitted.