Aminoalkylation of ‘Push-Pull’ Enamines Having a Methyl Group at the α-Position with Imines of Methyl 3,3,3-Trifluoropyruvate

Dmitriy A. Sibgatulin; Dmitriy M. Volochnyuk; Eduard B. Rusanov; Aleksandr N. Kostyuk

doi:10.1055/s-2006-926457

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Aminoalkylation of ‘Push-Pull’ Enamines Having a Methyl Group at the α-Position with Imines of Methyl 3,3,3-Trifluoropyruvate

Dmitriy A. Sibgatulin, Dmitriy M. Volochnyuk, Eduard B. Rusanov, Aleksandr N. Kostyuk*
Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska 5, Kyiv-94, 02094, Ukraine
Fax: +380(44)5373253; e-Mail: a.kostyuk@enamine.net;

Abstract

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Abstract

The reaction of ‘push-pull’ enamines having a methyl group at the α-position with imines of methyl 3,3,3-trifluoropyruvate was investigated. Structural sensitivity of the reaction was found and discussed. As a result, a set of β-dicarbonyl compounds bearing a protected amino acid moiety was obtained.

Key words

‘push-pull’ enamines - imines of methyl 3,3,3-trifluoropyruvate - aminoalkylation - protected amino acids

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References

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