Novel Approaches to Fused Phospha-Pyrimidines

Abstract

Simple methods for the preparation of phosphorus-containing fused pyrimidine analogues such as fused 1,5,2-diazaphosphinines from amidine derivatives of π-excessive heterocycles are described. The scope and limitations of the methodology are detailed.

Key words

phospha-pyrimidines - amidines - phosphorus(III) halides - phosphorylation - heterocyclization

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  Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Center as supplementary publication no. CCDC-256274 (27) and CCDC-256890 (38) and can be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [Fax: [phone]; E-mail: [e-mail]]