Planta Med 2006; 72(7): 659-661
DOI: 10.1055/s-2006-931568
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Resveratrol on Mast Cell Degranulation and Tyrosine Phosphorylation of the Signaling Components of the IgE Receptor

NaYeon Koo1 , DongIm Cho1 , YoungRan Kim1 , Hyun Jin Choi1 , Kyeong-Man Kim1
  • 1Department of Pharmacology, College of Pharmacy, Chonnam National University, Kwang-Ju, Korea
Further Information

Publication History

Received: September 8, 2005

Accepted: January 12, 2006

Publication Date:
24 April 2006 (online)

Abstract

The molecular mechanism of how resveratrol inhibits mast cell degranulation was studied by examining its effects on the signaling components of the high affinity IgE receptor (FcεRI) pathway. Resveratrol inhibited mast cell degranulation in a dose-dependent manner and reduced the FcεRI-mediated tyrosine phosphorylation of ERK and PLCγ1 but not of Syk and PLCγ2. U-73 122 and PD98059, which are PLC and MEK inhibitors, also had inhibitory effects on mast cell degranulation. These results suggest that FcεRI-mediated tyrosine phosphorylation of PLCγ1 and ERK could be potential cellular targets of resveratrol for the inhibition of mast cell degranulation.

Abbreviations

FcεRI:high affinity IgE receptor

ERK:extracellular signal regulated kinase

MEK:mitogen-activated protein kinase kinase

MAPK:mitogen-activated protein kinase

PLCγ:phospholipase C-γ

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Dr. Kyeong-Man Kim

Department of Pharmacology

College of Pharmacy

Chonnam National University

Kwang-Ju 500-757

Korea

Phone: +82-62-530-2936

Fax: +82-62-530-2949

Email: kmkim@chonnam.ac.kr