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Synfacts 2006(3): 0232-0232  
DOI: 10.1055/s-2006-931976
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Claisen-Schmidt Reaction in a Microfluidic Chip Reactor

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada
J.-X. Mu, X.-F. Yin*, Y.-G. Wang
Zhejiang University, Hangzhou, P. R. of China
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Publication History

Publication Date:
21 February 2006 (online)

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Significance

The Claisen-Schmidt reaction of benzaldehyde with acetone was examined in a microfluidic chip. Thus, this condensation was performed at room temperature for 8 minutes by introducing an ethanol solution of benzaldehyde with acetone and aqueous NaOH through the two inlets of the Y-shaped microchip reactor, giving 4-phenyl-3-buten-2-one in 93% conversion. In comparison, the standard batch system with vigorous stirring gave the product in only 60% conversion in the same reaction time. The reaction in the 300 µm wide microchannel with slug flow of aqueous and organic solutions afforded higher conversion (93%) than that in the 500 µm thick microchannel with laminar flow (80%).