Synthesis 2006(11): 1895-1897  
DOI: 10.1055/s-2006-942362
PSP
© Georg Thieme Verlag Stuttgart · New York

Zirconyl Chloride: A Useful Catalyst in the Pechmann Coumarin Synthesis

Juan C. Rodríguez-Domíngueza,b, Gilbert Kirsch*b
a Departamento de Química, Centro de Química Farmacéutica, Calle 200 y 21, Atabey, Playa, CP: 11600, Ciudad de la Habana, Cuba
b Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique (LIMBP), Université Paul Verlaine-Metz, 1, Boulevard Arago, 57078 Metz, France
Fax: +33(38)7315801; e-Mail: kirsch@univ-metz.fr;
Further Information

Publication History

Received 21 November 2005
Publication Date:
05 May 2006 (online)

Abstract

Coumarin derivatives were prepared using zirconyl chloride octahydrate (1%) as a Pechmann catalyst, either neat or in some cases employing small volumes of ethanol as solvent. As result of this work, coumarins were obtained in moderate to good yields.