Abstract
A stereoselective synthesis of (3R ,3aS ,6aR )-hexahydrofuro[2,3-b ]furan-3-ol, an important high affinity P2 -ligand, in high enantiomeric excess (>99%) is reported. The synthesis features an
ester-derived titanium enolate based highly stereoselective anti- aldol reaction as the key step.
Key Words
antiviral agents - asymmetric synthesis - chiral auxiliary - aldol reactions - fused-ring
systems
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