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Planta Med 2006; 72(10): 943-944
DOI: 10.1055/s-2006-946676
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Activity of Quinones from Teak (Tectona grandis) on Fungal Cell Wall Stress

Pattarawadee Sumthong1 , 3 , Robbert A. Damveld2 , Young H. Choi1 , Mark Arentshorst2 , Arthur F. J. Ram2 , Cees A. M. J. J. van den Hondel2 , Rob Verpoorte1
  • 1Division of Pharmacognosy, Section Metabolomics, Gorlaeus Laboratories, Institute of Biology, Leiden University, Leiden, The Netherlands
  • 2Fungal Genetics Research Group, Clusius Laboratories, Institute of Biology, Leiden University, Leiden, The Netherlands
  • 3Faculty of Resources and Environment, Kasetsart University, Si Racha Campus, Si Racha, Chonburi, Thailand
Further Information

Publication History

Received: January 30, 2006

Accepted: May 9, 2006

Publication Date:
21 June 2006 (online)

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Abstract

Teak (Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. Centrifugal partition chromatography was used to isolate the active compounds. By 1H-NMR the active compounds were identified as deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of 1,3-α-D-glucan synthase were used as a cell wall damage model. The result showed that deoxylapachol from T. grandis extract induced fungal cell wall stress.

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Prof. Dr. Rob Verpoorte

Division of Pharmacognosy

Section Metabolomics

Gorlaeus Laboratories

Institute of Biology

Leiden University

Einsteinweg 55

2300 RA, Leiden

The Netherlands

Fax: +31-71-527-4503

Email: Verpoort@chem.leidenuniv.nl