Palladium-Catalyzed Hydroxycarbonylation of Aryl and Vinyl Bromides by Mixed Acetic Formic Anhydride

Abstract

The palladium-catalyzed hydroxycarbonylation of aryl and vinyl bromides in the presence of acetic anhydride and lithium formate as a carbon monoxide source has been developed. The combination of palladium(II) acetate with 1,1′-bis(diphenylphosphino)ferrocene (dppf) is an efficient catalytic system when the reaction is carried out at 120 °C.

Key words

hydroxycarbonylation - palladium - catalysis - aryl bromides - carboxylic acids

References

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1

New address: A. Bessmertnykh, LIMSAG, Université de Bourgogne, UFR Science et Techniques, 9 av. A. Savary, BP 47870, Dijon 21078, France.

2

New address: J.-C. Caille, PPG-Sipsy, Z. I. La Croix Cadeau, B. P. 10079, Avrille 49242, France.

11

Aldrich Chemical spectra, FT-NMR, 1.

12

Aldrich Catalogue 2004-2005; Sigma-Aldrich Co., 2005 (www.sigmaaldrich.com).