Efficient Synthesis of Fluoroalkenes via Diethylzinc-Promoted Wittig Reaction

Abstract

The synthesis of α-fluoroacrylates and α-bromo-α-fluoroalkenes was achieved in very good yields using aldehydes and ketones, triphenylphosphine, diethylzinc as promoter, and ethyl dibromofluoroacetate or dibromofluoromethane, respectively. A change in the addition sequence was critical in order to obtain exclusively α-fluoroacrylates in good yields.

Key words

Wittig reaction - fluoroalkene - ketone - aldehyde - diethylzinc

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