Chiral phosphorus-based structures were investigated as N-activating groups for anodic
oxidation and as chiral inductors. This first study presents the results obtained
for pyrrolidine, with allyltrimethylsilane as a standard nucleophile. The methoxylated
compounds were obtained in excellent yields (82-98%). The diastereoselectivity of
the alkylation step (18-66%) is discussed with regard to the chiral auxiliary.
chiral auxiliaries - phosphorus derivatives - diastereoselective alkylation - secondary
amines - pyrrolidines
