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Synthesis 2006(22): 3888-3894
DOI: 10.1055/s-2006-950325
DOI: 10.1055/s-2006-950325
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Chiron Approach to (-)-Tetrahydrolipstatin
Further Information
Received
28 June 2006
Publication Date:
20 October 2006 (online)
Publication History
Publication Date:
20 October 2006 (online)
Abstract
An efficient chiron approach to the total synthesis of (-)-tetrahydrolipstatin is described. The main features of the synthetic strategy, which starts from tri-O-acetyl-d-glucal, are copper-mediated C-C bond formation, Frater alkylation, and Barton-McCombie deoxygenation.
Key words
(-)-tetrahydrolipstatin - anti-obesity - tri-O-acetyl-d-glucal - Frater alkylation
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