An Efficient Solid-Phase Synthesis of Substituted Isoxazole, Triazole, and Cycloalkadiene Derivatives Using Supported Selenium Resin

Yu-Guang Wang; Wei-Ming Xu; Xian Huang

doi:10.1055/s-2006-950366

PAPER

An Efficient Solid-Phase Synthesis of Substituted Isoxazole, Triazole, and Cycloalkadiene Derivatives Using Supported Selenium Resin

Yu-Guang Wang^a, Wei-Ming Xu^a, Xian Huang*^a,b
^a Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou 310028, P. R. of China
^b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. of China
Fax: +86(571)88807077; e-Mail: huangx@mail.hz.zj.cn;

Abstract

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Abstract

We have developed efficient methods for the syntheses of 3,5-disubstituted isoxazoles and 1,2,3-triazoles, and 1,3- and 1,4-cycloalkadiene derivatives using polymer-supported selenium resin. The advantages of these methods include straightforward operation, lack of odor, good stability, and high purity of the products.

Keywords

1,3-dipolar cycloaddition - Diels-Alder reaction - polymer-supported selenium resin - solid-phase synthesis - heterocycles

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