Synthesis of Novel Steroidal Bioconjugates with AZT and Phosphorus

Peiyuan Jin; Kai Liu; Sanhao Ji; Yong Ju; Yufen Zhao

doi:10.1055/s-2006-958966

PAPER

Synthesis of Novel Steroidal Bioconjugates with AZT and Phosphorus

Peiyuan Jin^a, Kai Liu^a, Sanhao Ji^a, Yong Ju*^a,b, Yufen Zhao^a
^a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China
e-Mail: juyong@tsinghua.edu.cn;
^b National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China

Abstract

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Abstract

Some novel asymmetry steroidal phosphates, phosphorothioates, phosphoroselenoates, and phosphoramidates were synthesized by oxidation or conjugation with amines using the Atherton-Todd reaction. The structures were confirmed by ¹H NMR, ³¹P NMR, and ESI-MS spectroscopy.

Key words

steroidal bioconjugate - AZT - phospholipid - phosphoramidate

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References

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