An Efficient Synthetic Route to Novel 3-Alkyl- and 3-Aryl-4-iodophenols

Gesine J. Hermann; Michael C. Annis; Peter D. Edwards; Marta Corrales; Lucía Díaz; Robert A. Goodnow

doi:10.1055/s-2007-1000860

PAPER

An Efficient Synthetic Route to Novel 3-Alkyl- and 3-Aryl-4-iodophenols

Gesine J. Hermann*^a, Michael C. Annis^a, Peter D. Edwards^a, Marta Corrales^a, Lucía Díaz^a, Robert A. Goodnow^b
^a ChemOvation Ltd., Graylands, Langhurstwood Road, Horsham, West Sussex, RH12 4QD, UK
Fax: +44(1403)276501; e-Mail: gesine.hermann@chemovation.com;
^b Roche Research Center, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA

Abstract

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Abstract

An efficient method for the preparation of novel 3-alkyl- and 3-aryl-4-iodophenols from 3-alkyl- and 3-arylphenols is described.

Key words

phenols - halogenation - deiodination - iodine monochloride - Suzuki reaction

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References

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