Unsymmetrical disulfides have been prepared from the corresponding thiols and bis-(5,5-dimethyl-2-thiono-1,3,2-dioxaphosphorinanyl)disulfide
under mild conditions with good to excellent yields. The method can be applied to
thiols bearing neutral, aromatic, basic or acidic functionalities with variable length
of carbon chain.
unsymmetrical disulfides - alkanethiols -
l-cysteine - thiophenol