Synthesis of Thiophene Analogues of the Tacrine Series

David Thomae; Gilbert Kirsch; Pierre Seck

doi:10.1055/s-2007-965944

PAPER

Synthesis of Thiophene Analogues of the Tacrine Series

David Thomae^a, Gilbert Kirsch*^a, Pierre Seck^b
^a Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, FR CNRS 2843, Université Paul Verlaine-Metz, 1 Boulevard Arago, 57070 Metz, France
Fax: +33(3)87325801; e-Mail: kirsch@univ-metz.fr;
^b Laboratoire de Chimie, Faculté des Sciences, de la Technologie et de la Communication Université du Luxembourg, 162a avenue de la Faïencerie, 1511 Luxembourg, Luxembourg

Abstract

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Abstract

3-Amino-2-cyanothiophenes condensed with cyclanones and afforded analogues of Velnacrine in two or three steps. Condensation under Friedländer’s conditions gave tacrine analogues in one step.

Key words

Alzheimer’s disease - tacrine analogues - Friedländer reaction - condensation - aminothiophene carbonitrile

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References

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