Total Synthesis of Vulnibactin: A Natural Product Iron Chelator

Abstract

A short, high-yield, flexible synthesis is described for accessing vulnibactin and related siderophores, e.g., vibriobactin analogues and homologues. The spectral properties of the synthetic vulnibactin are identical with those reported for the natural product, thus confirming the proposed structure of vulnibactin.

Key words

chelates - iron - medicinal chemistry - natural products - receptors

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