Synthesis, Table of Contents SHORTPAPER© Georg Thieme Verlag Stuttgart · New YorkA Microwave-Assisted Alternative Synthesis of 8-Amino-2-methyl-3,4-dihydroisoquinolin-1-oneSteve C. Glossop*AstraZeneca Plc., Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK Fax: +44(1625)586707; e-Mail: steve.glossop@astrazeneca.com; Recommend Article Abstract Buy Article All articles of this category Abstract A shorter, alternative synthesis of 8-amino-2-methyl-3,4-dihydroisoquinolin-1-one is described in 32% overall yield, over three steps starting from commercially available 2-methyl-6-nitrobenzonitrile. The synthesis includes two ‘one-pot’ procedures in which the key process involves the microwave-assisted hydrolysis of a nitrile group followed by lactamization under elevated temperatures. Key words lactam - microwaves - cyclization - Bredereck’s reagent - isoquinolinone Full Text References References <A NAME="RP14106SS-1">1</A> Imbach P, Kawahara E, Konishi K, Matsuura N, Miyake T, Ohmori O, Roesel J, Teno N, and Umemura I. inventors; PCT Int. Appl. WO 2006021454. ; Chem. Abstr. 2006, 144, 274291 <A NAME="RP14106SS-2">2</A> Stadtmueller H, Engelhardt H, Steegmaier M, Baum A, Guertler U, Schoop A, Quant J, Solca F, Hauptmann R, Reiser U, Zahn SK, and Herfurth L. inventors; PCT Int. Appl., WO 2006021544. ; Chem. Abstr. 2006, 144, 292768 <A NAME="RP14106SS-3">3</A> Hewson AT. Hughes K. Richardson SK. Sharpe DA. Wadsworth AH. J. Chem. Soc., Perkin Trans. 1 1991, 1565 <A NAME="RP14106SS-4">4</A> Bondinell WE, and Pendleton RG. inventors; Eur. Pat. Appl. EP0002624. ; Chem. Abstr. 1979, 92, 22401 <A NAME="RP14106SS-5">5</A> Ozaki F, Ishibashi K, Ikuta H, Ishihara H, and Souda S. inventors; PCT W09518097. ; Chem. Abstr. 1995, 123, 256357 <A NAME="RP14106SS-6">6</A> Haefliger W. Knecht H. Tetrahedron Lett. 1984, 25: 285 <A NAME="RP14106SS-7">7</A> Siu J. Baxendale IR. Ley SV. Org. Biomol. Chem. 2004, 2: 160
