Synfacts 2007(10): 1065-1065  
DOI: 10.1055/s-2007-969011
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Stereoselective Palladium-Catalyzed Addition of Boronic Acids onto Aldehydes

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
A. Novodomskà, M. DudiÈovà, F. R. Leroux, F. Colobert*
Université Louis Pasteur, Strasbourg, France
Further Information

Publication History

Publication Date:
07 November 2007 (online)

Significance

The authors of this report used palladium catalysis to diastereoselectively generate diaryl methanols with moderate selectivity. One attractive feature is the ability to apply the slightly less expensive palladium catalyst (compared to rhodium). The use of boronic acid substrates as coupling partners is also an interesting aspect. The authors must first convert 2-bromobenzaldehyde in a two-step sequence into the chiral sulfinyl compound.