A Highly Efficient and Useful Synthetic Protocol for the Synthesis of Bis[aryl(diethoxyphosphoryl)methyl]amines from Aromatic Aldehydes Using Acetyl Chloride as an Efficient Catalyst

Babak Kaboudin; Ehsan Jafari

doi:10.1055/s-2007-983720

PAPER

A Highly Efficient and Useful Synthetic Protocol for the Synthesis of Bis[aryl(diethoxyphosphoryl)methyl]amines from Aromatic Aldehydes Using Acetyl Chloride as an Efficient Catalyst

Babak Kaboudin*, Ehsan Jafari
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45195-1159, Iran
Fax: +98(241)4249023; e-Mail: kaboudin@iasbs.ac.ir;

Abstract

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Abstract

A highly efficient and useful method for the synthesis of bis[aryl(diethoxyphosphoryl)methyl]amines has been developed. The treatment of aromatic aldehydes with ammonia followed by reaction with diethyl phosphite in the presence of acetyl chloride as catalyst gives bis[aryl(diethoxyphosphoryl)methyl]amines. This method is easy, rapid, and a high yielding method for the synthesis of bis[aryl(diethoxyphosphoryl)methyl]amines with good diastereoselection from simple starting materials.

Key words

acetyl chloride - diethyl phosphite - aldehyde - bis[aryl(diethoxyphosphoryl)methyl]amine - addition reaction

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