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Synthesis 2007(22): 3553-3557
DOI: 10.1055/s-2007-990811
DOI: 10.1055/s-2007-990811
PAPER
© Georg Thieme Verlag Stuttgart · New YorkA Novel Short and Efficient Synthetic Route to the Antimalarial Agent FR900098 and Derivatives
Further Information
Received
23 July 2007
Publication Date:
25 September 2007 (online)
Publication History
Publication Date:
25 September 2007 (online)
Abstract
We report here a new operationally simple, economical, and environmentally friendly multicomponent approach for a one-pot synthesis of the antimalarial agent FR900098. The reaction allows the fast construction of the compound from simple and commercially available substrates and reagents and is also applicable to the synthesis of modified derivatives of FR900098.
Key words
drugs - multicomponent reactions - sulfonamides - sulfones - phosphonic acid
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