Anti-Allergic Prenylated Flavonoids from the Roots of Sophora flavescens

Abstract

The bioassay-guided fractionation of the MeOH extract from the root of Sophora flavescens led to the isolation of eight known prenylated flavonoids (1 - 8) responsible for the in vitro anti-allergic activity. Among them, kushenol N (3), sophoraflavanone G (6), and leachianone A (7) demonstrated significant inhibition of the release of β-hexosaminidase from cultured RBL-2H3 cells with IC₅₀ values ranging from 15 to 30 μM.

Sophora flavescens - Leguminosae - anti-allergic activity - prenylated flavonoids

References

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1 Both authors contributed equally