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Planta Med 2008; 74(4): 407-410
DOI: 10.1055/s-2008-1034330
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Anti-Infective and Cytotoxic Compounds Present in Blepharodon nitidum

José C. Aponte1 , Yannick Estevez2 , Robert H. Gilman3 , 4 , Walter H. Lewis5 , Rosario Rojas4 , Michel Sauvain2 , Abraham J. Vaisberg4 , Gerald B. Hammond1
  • 1Department of Chemistry, University of Louisville, Louisville, KY, U.S.A.
  • 2UMR 152 IRD - Université de Toulouse III, Mission IRD, Lima, Perú
  • 3Department of International Health, Johns Hopkins University School of Public Health, Baltimore, MD, U.S.A.
  • 4Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
  • 5Department of Biology, Washington University, St. Louis, MO, U.S.A.
Further Information

Publication History

Received: December 1, 2007 Revised: January 27, 2008

Accepted: February 6,2008

Publication Date:
11 March 2008 (online)

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Abstract

A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3β-ol and 25-hydroperoxycycloart-23-en-3β-ol, exhibited in vitro anti-Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

Key words

Blepharodon nitidum - Asclepiadaceae - hydroperoxycycloartanes - antileishmania - anti-infective - cytotoxic

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Prof. Dr. Gerald Hammond

Department of Chemistry

University of Louisville

Louisville

KY 40292

USA

Phone: +1-502-852-5998

Fax: +1-502-852-3899

Email: gb.hammond@louisville.edu

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