Eur J Pediatr Surg 2008; 18(3): 202-204
DOI: 10.1055/s-2008-1038591
Case Report

© Georg Thieme Verlag KG Stuttgart · New York

Outcome of an Adult Granulosa Cell Tumour in an Adolescent Initially Managed by Laparoscopy

I. Lacreuse1 , F. Becmeur1 , L. Marcelin2 , P. Lutz3
  • 1Pediatric Surgery Department, University Hospital of Strasbourg, Strasbourg, France
  • 2Histopathology Department, University Hospital of Strasbourg, Strasbourg, France
  • 3Pediatric Oncology Department, University Hospital of Strasbourg, Strasbourg, France
Further Information

Publication History

received December 15, 2007

accepted after revision March 5, 2008

Publication Date:
21 May 2008 (online)

Abstract

Adult granulosa cell tumour is rarely encountered in adolescents. Tumours in their early stages have a favourable prognosis whereas those in advanced stages have a poor outcome. Documented series of tumours at advanced stages are very rare and follow-up is difficult because of the frequently prolonged intervals before progression of the tumour. That may explain why it is very difficult to define a consensual management strategy with or without adjuvant therapy such as chemotherapy or radiation therapy. We describe a case of adult granulosa cell tumour in a 14-year-old girl who initially underwent laparoscopy for an “unsuspicious” cyst. Management was then modified according to oncological guidelines because of the histological nature of this cyst.

References

  • 1 Ates O, Karakaya E, Hakgüder G, Olguner M, Seçil M, Akgür F M. Laparoscopic excision of a giant ovarian cyst after ultrasound-guided drainage.  J Pediatr Surg. 2006;  41 E9-E11
  • 2 Brandt M L, Helmrath M A. Ovarian cysts in infants and children.  Semin Pediatr Surg. 2005;  14 78-85
  • 3 Calaminus G, Wessalowski R, Harms D, Göbel U. Juvenile granulosa cell tumors of the ovary in children and adolescents: results from 33 patients registered in a prospective cooperative study.  Gynecol Oncol. 1997;  65 447-452
  • 4 Cass D L, Hawkins E, Brandt M L, Chintagumpala M, Bloss R S, Milewicz A L, Minifee P K, Wesson D E, Nuchtern J G. Surgery for ovarian masses in infants, children, and adolescents: 102 consecutive patients treated in a 15-year period.  J Pediatr Surg. 2001;  36 693-699
  • 5 Ehrlich P F, Teitelbaum D H, Hirschl R B, Rescorla F. Excision of large cystic ovarian tumors: combining minimal invasive surgery techniques and cancer surgery - the best of both worlds.  J Pediatr Surg. 2007;  42 890-893
  • 6 Eltabbakh G H, Charboneau A M, Eltabbakh N G. Laparoscopic surgery for a large benign ovarian cysts.  Gynecol Oncol. 2008;  108 72-76
  • 7 Kdous M, Hachicha R, Gamoudi A. Early isosexual precocious pseudopuberty revealing a juvenile granulosa cell tumor in a six-year-old girl.  Gynecol Obstet Fertil. 2004;  32 311-314
  • 8 Martelli H, Patte C. Gonadal tumours in children.  Arch Ped. 2003;  10 246-250
  • 9 Powell J L, Otis C N. Management of advanced juvenile granulosa cell tumor of the ovary.  Gynecol Oncol. 1997;  64 282-284
  • 10 Savage P, Constenla D, Fisher C, Shepherd J H, Barton D PJ, Blake P, Gore M E. Granulosa cell tumours of the ovary: demographics, survival and management of advanced disease.  Clincal Oncol. 1998;  10 242-245
  • 11 Skinner M A, Schlatter M G, Heifetz S A. et al . Ovarian neoplasms in children.  Arch Surg. 1993;  128 849-854

 Miss
Isabelle Lacreuse, Ph.D. 

Pediatric Surgery Department
University Hospital of Strasbourg

Avenue Moliere

67098 Strasbourg

France

Email: isabelle.talon2@chru-strasbourg.fr

    >