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Synfacts 2008(3): 0220-0220  
DOI: 10.1055/s-2008-1042651
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Vinblastine

Contributor(s): Philip Kocienski
T. Miyazaki, S. Yokoshima, S. Simizu, H. Osada, H. Tokuyama, T. Fukuyama*
University of Tokyo and RIKEN, Wako, Japan
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Publication History

Publication Date:
21 February 2008 (online)

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Significance

Vinblastine is used to treat leukemia and lymphoma patients. The present synthesis, a modification of one reported in 2002, incorporated an alkyne group in order to create analogues by Pd-catalyzed coupling procedures.