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Synfacts 2008(3): 0221-0221  
DOI: 10.1055/s-2008-1042656
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Phomopsin B

Contributor(s): Philip Kocienski, Arndt W. Schmidt
J. S. Grimley, A. M. Sawayama, H. Tanaka, M. M. Stohlmeyer, T. F. Woiwode, T. J. Wandless*
Stanford University, USA
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Publication History

Publication Date:
21 February 2008 (online)

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Significance

Phomopsin B is a potent micro­tubule-destabilizing agent, isolated from the fungus Phomopsis leptostromiformis. In the present synthesis fully functionalized building blocks are combined by peptide coupling reactions followed by a late-stage macrocyclization. Phomopsin B was obtained after 26 steps.