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Synfacts 2008(3): 0228-0228
DOI: 10.1055/s-2008-1042660
DOI: 10.1055/s-2008-1042660
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Iejimalide B
D. Schweitzer, J. J. Kane, D. Strand, P. McHenry, M. Tenniswood, P. Helquist*
University of Notre Dame, USA
Further Information
Publication History
Publication Date:
21 February 2008 (online)
Significance
Iejimalide B is a marine microbial metabolite with growth inhibitory activity against a wide range of human tumours. The asymmetric synthesis of alkyne fragments E and I via the Carreira alkynylation and the Marshall propargylation respectively are highlights of the synthesis.