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Synfacts 2008(3): 0226-0226  
DOI: 10.1055/s-2008-1042663
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Communesin F

Contributor(s): Philip Kocienski
J. Yang, H. Wu, L. Shen, Y. Qin*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
21 February 2008 (online)

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Significance

Qin and co-workers have accomplished the synthesis of heptacyclic communesin F (a Penicillium metabolite) in 23 steps (3% overall). The two adjacent quaternary centers were constructed sequentially by a carbene insertion to give A and a Claisen rearrangement (C→D).