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Synfacts 2008(3): 0232-0232
DOI: 10.1055/s-2008-1042665
DOI: 10.1055/s-2008-1042665
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (-)-Batzelladine D
P. A. Evans*, J. Qin, J. E. Robinson, B. Bazin
University of Liverpool, UK and Indiana University, Bloomington, USA
Further Information
Publication History
Publication Date:
21 February 2008 (online)
Significance
Batzelladine D is a marine alkaloid with no known biological activity; however, other members of the batzelladine family have varied activities and the synthesis of the batzelladine tricyclic core is an important goal. This synthesis makes good use of azides as masked amines and a radical cyclization to construct the five-membered ring.