Synfacts 2008(3): 0288-0288  
DOI: 10.1055/s-2008-1042696
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Nickel-Catalyzed Regioselective Olefin-Directed Cross-Coupling Reaction

Contributor(s): Mark Lautens, Valentina Aureggi
R. L. Rogers, J. L. Moore, T. Rovis*
Colorado State University, Fort Collins, USA
Further Information

Publication History

Publication Date:
21 February 2008 (online)

Significance

The development of an efficient catalytic regioselective alkylation of cyclic anhydrides through olefin-directed nickel insertion and subsequent cross-coupling is reported. The corresponding alkylated products are obtained in good yields and regioselectivities.