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Synthesis 2008(11): 1679-1681  
DOI: 10.1055/s-2008-1067040
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

Rapid and Convenient Microwave-Assisted Synthesis of Primary Amines via Reductive N-Alkylation of Methyl Carbamate with Aldehydes

Fredrik Lehmann, Martin Scobie*
Biovitrum AB, Discovery Research, 112 76 Stockholm, Sweden
Fax: +46(8)6972533; e-Mail: martin.scobie@biovitrum.com;
Further Information

Publication History

Received 20 February 2008
Publication Date:
29 April 2008 (online)

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Abstract

Microwave-assisted reductive alkylation of methyl carbamate with a range of aldehydes provides, after basic work-up, an experimentally simple, one-pot method for rapid functional group interconversion of structurally diverse aldehydes into primary amines. The method has several advantages over more traditional methods of carrying out this transformation and is particularly amenable­ to high-throughput synthesis.

Key words

aminations - aldehydes - reductive alkylation - carbamates - amines - microwave synthesis

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