C _3v -Symmetrical Calix[6]arenes

Significance

The authors report the synthesis of the C _3v symmetrical calix[6]arene derivative 5 from the C _6v symmetrical compound 1. Their synthetic route involves the introduction of a guest molecule (AcNH₂), formation of first the dimeric and then the monomeric Zn complexes 3 and 4 and the Boc-protection of the free amine sites. Removal of the metal ion yields 5 whose six amine groups are protected in the 1,3- and 5-position.