First Synthesis of 3,6′- and 3,7′-Biquinoline Derivatives

Abstract

The preparation of new 3,6′- and 3,7′-biquinoline derivatives was achieved by microwave-assisted Suzuki cross-coupling between N-protected 6- or 7-bromoquinolin-2(1H)-ones and quinolin-3-ylboronic acid. Moreover, a new synthesis of 7-bromoquinolin-2(1H)-one leading solely to the 7-substituted isomer was carried out.

Keywords

quinoline - quinolinone - 6-bromoquinolin-2(1H)-one - 7-bromoquinolin-2(1H)-one - Suzuki cross-coupling

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