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Synthesis 2008(16): 2665-2667  
DOI: 10.1055/s-2008-1067180
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

Ring-Closing Metathesis as a Key Step in the Synthesis of 2-Pyridones and Pyridine Triflates

Timothy J. Donohoe*a, Lisa P. Fishlocka, Panayiotis A. Procopioub
a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
e-Mail: timothy.donohoe@chem.ox.ac.uk;
b GlaxoSmithKline Research & Development Limited, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Further Information

Publication History

Received 19 May 2008
Publication Date:
17 July 2008 (online)

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Abstract

The ring-closing metathesis transformation has been employed to construct a library of functionalized 2-pyridones and pyridine triflates. Using this mild approach, a range of substituent patterns can be built into the aromatic core, including groups which can be demanding to incorporate using alternative protocols.

Key words

ring-closing metathesis - elimination - 2-pyridone - pyridine - triflation

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