Conversion of a Vinyl Grignard Reagent to a 1,2-Dimetalated Ethane Synthon

doi:10.1055/s-2008-1077798

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Synfacts 2008(6): 0636-0636
DOI: 10.1055/s-2008-1077798

Metal-Mediated Synthesis

Conversion of a Vinyl Grignard Reagent to a 1,2-Dimetalated Ethane Synthon

Contributor(s): Paul Knochel, Tobias Thaler
R. Tanaka, H. Sanjiki, H. Urabe*
Tokyo Institute of Technology, Yokohama, Japan

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Publication History

Publication Date:
21 May 2008 (online)

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Significance

A synthon for 1,2-dimetalated ethane was efficiently synthesized by the reaction of CpYH₂ with vinyl Grignard reagent. It was used in the reaction with triple C-C bonds carboxylic esters.