DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 57 · January 2019 DOI: 10.1055/s-008-42145

35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Deutsche Arbeitsgemeinschaft zum Studium der Leber (GASL)

Heidelberg, 22.–23.02.2019
Kongresspräsident: Prof. Dr. Ralf Bartenschlager


P1.2
Alquzi, S; Elshaarawy, O; Mueller, J; Rausch, V; Silva, I; Peccerella, T; Seitz, HK; Mueller, S: Liver stiffness decreases in response to portal pressure lowering drugs
P1.4
Borkham-Kamphorst, E; Van de Leur, E; Haas, U; Weiskirchen, R: LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses
P1.5
Bowlus, CL; Pockros, PJ; Kremer, AE; Parés, A; Forman, LM; Drenth, JPH; Ryder, S; Terracciano, L; Jin, Y; Liberman, A; Pencek, R; MacConell, L; Bedossa, P: Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
P1.6
Brosch, M; Kattler, K; Herrmann, A; Schönfels, W von; Nordström, K; Seehofer, D; Damm, G; Becker, T; Zeissig, S; Nehring, S; Reichel, F; Moser, V; Thangapandi, RV; Stickel, F; Baretton, G; Röcken, C; Muders, M; Matz-Soja, M; Krawczak, M; Gasparoni, G; Hartmann, H; Dahl, A; Schafmayer, C; Walter, J; Hampe, J: Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
P1.7
Buch, S; Stickel, F; Zoller, H; Ryan, E; Sharma, AD; Aigner, E; Griffiths, WJH; Gallati, S; Stewart, S; Lammert, F; Zeissig, S; Berg, T; Zwerina, J; McQuillin, A; Datz, C; Weiss, KH; Gotthardt, D; Morgan, MY; Hampe, J: Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
P1.8
Cai, C; Araos, J; Gaitantzi, H; Ebert, MP; Breitkopf-Heinlein, K: How endoglin modulates the hepatocytes' response to BMP-9
P1.9
Dewidar, B; Dropmann, A; Gould, K; Hartwig, V; Dormann, C; Dooley, S; Hammad, S: Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver
P1.10
Dooley, S; Fan, W; Hammad, S; Gould, K; Longerich, T; Liu, T; Chen, W; Liu, C; Hou, J; Jia, J; Sun, B: ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
P1.11
Elshaarawy, O; Alquzi, S; Rausch, V; Mueller, J; Silva, I; Peccerella, T; Seitz, HK; Mueller, S: Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis
P1.14
Ghallab, A; Maiju, M; Hassan, R; Zaza, A; Hofmann, U; Buhl, EM; Schneider, KM; Breuhahn, K; Seddek, A; Trautwein, C; Marx, A; Dooley, S; Longerich, T; Boor, P; Drasdo, D; Hengstler, JG: A mouse model of chronic liver disease progression and acute-on-chronic liver failure
P1.15
Ghennam, E; Zweerink, S; Nierhoff, D; Goeser, T; Steffen, HM; Toex, U; Schulte, S: The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?
P1.16
Haderer, M; Gschwendtner, H; Aschenbrenner, E; Pollinger, K; Schlosser, S; Gülow, K; Kunst, C; Müller-Schilling, M: Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
P1.17
Hammad, S; Dahmen, U; Othman, A; Recklinghausen, I von; Hengstler, JG; Klingmüller, U; Dooley, S: Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
P1.19
Hammad, S; Zhao, J; Yin, Y; Zaza, A; Drasdo, D; Hengstler, JG; Dooley, S: CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
P1.20
Han, M; Nwosu, ZC; Ebert, MP; Hammad, S; Dooley, S; Meyer, C: Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo
P1.21
Hohenester, S; Wimmer, R; Kremer, AE; Denk, G; Florian, R; Horst, D; Oude Elferink, R; Beuers, U: Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
P1.23
Itzel, T; Evert, M; Teufel, A: Hepamine 2.0
P1.25
Karatayli, E; Christidis, G; Hall, RA; Weber, SN; Dooley, S; Lammert, F; Karatayli, SC: Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
P1.26
P1.27
P1.28
Liu, K; Weiler, SME; Wan, S; Tóth, M; Poth, T; Pinna, F; Schmitt, J; Thomann, S; Heikenwälder, M; Schirmacher, P; Breuhahn, K: TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
P1.29
Lu, K; Görg, B; Zimmermann, M; Bidmon, HJ; Häussinger, D; Reichert, AS: Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia
P1.30
Möbus, S; Markovic, J; Manns, MP; Ott, M; Cantz, T; Sharma, AD: Functional microRNA screening to improve hepatocyte formation via direct reprogramming
P1.31
Mohamed, MR; Cubero, FJ; Zhao, G; Nevzorova, YA; Gassler, N; Davis, RJ; Trautwein, C: Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury
P1.32
Niemietz, C; Guttmann, S; Sandfort, V; Schmidt, H: SERPINA1 levels dictate TTR expression in HepG2 cells
P1.34
Pohl, J; Rißel, M; Horner, R; Kluge, M; Moosburner, S; Gaßner, J; Pratschke, J; Sauer, IM; Raschzok, N: Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
P1.35
Poppenborg, F; Bopp, C; Nicklas, A; Lammert, F; Weber, SN: Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle
P1.36
P1.38
Reiter, FP; Ye, L; Bösch, F; Wimmer, R; Artmann, R; Ziesch, A; Kanitz, V; Mayr, D; Trauner, M; Regel, I; Gerbes, AL; Mayerle, J; Hohenester, S; de Toni, E; Denk, G: Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
P1.39
Scherm, S; Haderer, M; Aschenbrenner, E; Pollinger, K; Schlosser, S; Kunst, C; Müller-Schilling, M: Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
P1.40
Schneider, KM; Liao, L; Galvez, EJC; Frissen, M; Marschall, HU; Su, H; Hatting, M; Wahlström, A; Haybaeck, J; Puchas, P; Mohs, A; Peng, J; Jung, J; Reißing, J; Zimmermann, HW; Longerich, T; Strowig, T; Liedtke, C; Cubero, FJ; Trautwein, C: Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
P1.42
Schwarzkopf, KM; Rüschenbaum, S; Barat, S; Cai, C; Mücke, MM; Fitting, D; Weigert, A; Brüne, B; Zeuzem, S; Welsch, C; Lange, CM: IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
P1.43
Silva, I; Rausch, V; Teresa, P; Gunda, M; Sebastian, M: Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels
P1.44
Stickel, F; Lutz, P; Buch, S; Rausch, V; Silva, I; Fischer, J; Nischalke, HD; Rosendahl, J; Krawczyk, M; Casper, M; Zopf, S; Marhenke, S; Lammert, F; Vogel, A; Datz, C; Sharma, R; Eyer, F; Spengler, U; Felden, J von; Zeissig, S; Canbay, A; Grove, J; Aithal, G; McQuillin, A; Valenti, L; Weiss, KH; Mueller, S; Morgan, MY; Gotthardt, D; Berg, T; Hampe, J: Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
P1.45
Stindt, J; Dröge, C; Wammers, M; Philippski, P; Wiek, C; Hanenberg, H; Häussinger, D; Keitel, V: A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
P1.47
Vogel, K; Zhuang, Y; Haifeng, X; Sundaram, B; Huang, J; Reich, M; Tumanov, AV; Polz, R; Scheller, J; Ware, CF; Pfeffer, K; Keitel, V; Häussinger, D; Pandyra, AA; Lang, KS; Lang, PA: B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
P1.48
Wang, B; Kaufmann, B; Zhang, X; Mogler, C; Friess, H; Hüser, N; Figura, G von; Hartmann, D: Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice
P1.49
Wang, L; Schmiel, M; Yu, X; Macheleidt, I; Dalvi, P; Eischeid-Scholz, H; Büttner, R; Odenthal, M: Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
P1.50
Weiskirchen, R; Kim, P; Weiskirchen, S; Uerlings, R; Kueppers, A; Stellmacher, F; Viveiros, A; Zoller, H: Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)