zeitschrift für gastroenterologie
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Abadi, Z
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Abdallah, AT
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Ahmadzadehfar, H
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
Aigner, E
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Aithal, G
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Alavian, SM
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Albrecht, T
Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome
Alexandrov, A
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Alexandrov, T
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism
Al-Herwi, E
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Aliabadi, E
Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B
Alizor, H
Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
Allweiss, L
The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Al-Mahtab, M
Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
Alonso-Pena, M
Suppression of bile acid-CoA:amino acid N-acyltransferase gene expression by the interleukin-6-type cytokine Oncostatin M
Alquzi, S
Liver stiffness decreases in response to portal pressure lowering drugs
Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis
Al-Saeedi, M
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy
Alvarez-Silva, C
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Aly, M
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Amer, W
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Andersen, JB
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Andreas, T
Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose
Angel, P
Hepatic Progenitor Cells/Oval Cells Mediate Pro-inflammatory Responses upon Liver Injuries
Antoni, C
Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose
Appenrodt, B
Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten
Aprupe, L
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
Araos, J
How endoglin modulates the hepatocytes' response to BMP-9
Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma
Arroyo, V
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Artmann, R
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Arumugam, M
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Aschenbrenner, E
Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?
Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion
Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma
Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis
Asen, T
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Ashfaq, I
Evaluation of hepatoprotective potential of Itraconazole in CCl4 induced liver injury mouse model
Aßmuth, S
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Atkinson, SR
In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Augustin, H
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Awad, M
Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival
Baba, HA
The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Backhus, J
Der Einsatz einer permanenten Aszitesdrainage bei Patienten mit therapierefraktärem Aszites bei Peritonealkarzinose und end-stage-Leberzirrhose: Vergleich des Komplikationen- und Sicherheitsprofils
Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose
Backu, E
Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?
Badenhoop, K
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Balp, MM
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Bals, R
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Banales, JM
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
Bang, C
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Bantel, H
Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Barat, S
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Baretton, G
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Barikbin, R
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice
Barreto, G
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Bartenschlager, R
Identification of host cell factors involved in hepatitis C virus replication
Role of autophagy in hepatitis C virus replication
Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression
Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β
The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver
Lipid droplets and associated proteins in viral hepatitis
Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
Bastgen, D
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Bauer, M
Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis
Bauer, T
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Baumann, S
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
Baumert, T
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Bazinet, M
Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
Bazylak-Kapps, B
Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis
Bechmann, L
Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Becker, D
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Becker, T
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Bedossa, P
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Beer, B
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Bender, S
Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
Bendtsen, F
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Benedé-Ubieto, R
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Bengsch, B
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Benjamin, G
Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy
Berg, C
Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)
Berg, T
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Bergen, M von
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
Berger, A
Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose
Bergheim, D
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
Berkhout, L
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice
Berres, ML
Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
Best, J
Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Bettinger, D
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Beuers, U
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
Bidmon, HJ
Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia
Biedenbach, J
Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)
Bilzer, M
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Binder, H
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Binder, M
Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses
Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma
Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
Bockmann, JH
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Bode, JG
Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression
Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β
Deletion of thrombin receptor PAR4 attenuates the development of insulin resistance and NAFLD in mouse fed high-fat diet
Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3
Hepatocytes induces properties of wound healing type and regulatory macrophages in co-cultivated BMDM
Boden, K
Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience
Boettler, T
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Type I Interferons promote maintenance and function of follicular T helper cells in vitro
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Böhm, K
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Böhm, S
Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
Boor, P
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Bopp, C
Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle
Borkham-Kamphorst, E
LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses
Bosch, M
Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver
Bösch, F
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Bosserhoff, AK
Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes
Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes
Pregnancy-associated plasma protein-A as potential novel target and serum marker for hepatic fibrosis
The potent modulator of cholesterol biosynthesis insulin-induced gene 1 (INSIG1) is a novel hypoxia-regulated tumor suppressor in hepatocellular carcinoma
Variation of the expression of different Histone deacetylases (HDACs) and the functional effects of HDAC-inhibitors in hepatocellular carcinoma
Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma
Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma
Bovensiepen, C
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
Bowlus, CL
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Branchi, V
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Brandt, EF
Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
Brass, C
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Breitkopf-Heinlein, K
How endoglin modulates the hepatocytes' response to BMP-9
Characterization of the liver phenotype of the BMP-9 knock-out mouse
Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma
Breuhahn, K
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
Brinz, S
Der Einsatz einer permanenten Aszitesdrainage bei Patienten mit therapierefraktärem Aszites bei Peritonealkarzinose und end-stage-Leberzirrhose: Vergleich des Komplikationen- und Sicherheitsprofils
Brodesser, S
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Broering, R
The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Bröker, K
Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa
Brooks, J
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Brosch, M
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Loss of zonation in end stage liver disease revealed by in situ omics
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Bruckmann, A
Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration
Brückner, S
Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening
Brugger, M
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
Brügger, B
Identification of host cell factors involved in hepatitis C virus replication
Brüne, B
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Brunner, SM
Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation
Bruns, T
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis
Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Buch, S
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Büchetr, M
Intravenous therapy of hepatic encephalopathy with L-ornithine l-aspartate (Lola) is safe and very effective
Büchler, MW
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
Büchter, M
Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease
Buck, A
Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)
Budczies, J
RSPO2 gene rearrangement – a new cancer driver in the liver
Budeus, B
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Buechler, C
Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration
Buechter, M
Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients
Characteristics and outcome of 544 patients with autoimmune hepatitis (AIH) – a single centre experience
Buettner, N
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
Buettner, R
Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma
Buggisch, P
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Buhl, EM
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Burkhardt, R
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Buti, M
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Büttner, R
Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells
Byrtus, A
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Byrtus, J
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Cai, C
How endoglin modulates the hepatocytes' response to BMP-9
Characterization of the liver phenotype of the BMP-9 knock-out mouse
Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Cai, J
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Calvisi, DF
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)
The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Canbay, A
Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten
Cantz, T
Functional microRNA screening to improve hepatocyte formation via direct reprogramming
Carambia, A
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Caruso, S
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Casey, J
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Casillas, R
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Casper, M
Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Castven, D
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Chalmers, J
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Chamulitrat, W
iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet
Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism
Liver specific-deletion of FATP4 increases hepatic triglycerides upon D8-glycerol administration: a stable isotope labelling study
iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes
Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress
Chatzigeorgiou, A
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
Chavakis, T
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Che, L
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Chen, C
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Chen, LS
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
Chen, W
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Chen, X
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Cheng, X
Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma
Cheng, Y
iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes
Christ, B
Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids
Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
Christen, U
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Christiansen, N
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Christidis, G
Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
Chung, KJ
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Churin, Y
CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice
Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten
Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen
Ciesek, S
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
Cigliano, A
Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)
Claria, J
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Clees, C
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Conrad, C
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Conrad, R
Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival
Cornberg, M
Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Coskun, Ü
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Cosma, LS
Delirium – of outstanding relevance for the interprofessional team on an intensive care unit with focus on hepatology
Cramer, T
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
Cubero, FJ
Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice
Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing
Czauderna, C
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Dabere, O
Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
Dabiri, Y
Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma
Dächert, C
Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma
Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
Dahl, A
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Dahmen, U
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
Dalvi, P
Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma
Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
Damm, G
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Dammermann, W
Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa
Dandri, M
The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Daniel, S
Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose
Datz, B
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Datz, C
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Davis, RJ
Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury
Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice
Dejardin, E
Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
De Keizer, B
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
De la Torre, C
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Demir, M
No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany
Denk, A
Delirium – of outstanding relevance for the interprofessional team on an intensive care unit with focus on hepatology
Denk, G
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
De Ponti, A
Hepatic Progenitor Cells/Oval Cells Mediate Pro-inflammatory Responses upon Liver Injuries
de Toni, E
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Deutschmann, K
Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
Dewidar, B
Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration
Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver
Dietrich, P
The potent modulator of cholesterol biosynthesis insulin-induced gene 1 (INSIG1) is a novel hypoxia-regulated tumor suppressor in hepatocellular carcinoma
Variation of the expression of different Histone deacetylases (HDACs) and the functional effects of HDAC-inhibitors in hepatocellular carcinoma
Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma
Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma
Dikopoulos, N
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Ding, H
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Djouder, N
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Dobrikova, K
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Doleschel, D
Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing
Dombrowski, F
Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)
Hepatocellular clear cell foci in ChREBP knockout and wild type mice after intraportal pancreatic islet transplantation – a long time experiment
Donakonda, S
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver
Dong, S
A targeted screen to identify relevant oncogenes in RAS activated liver cancer
Dooley, S
Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer
Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration
Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
Aged Abcb4-/- mice upon acute sublethal chemical insult recapitulate features of acute-on-chronic liver failure in patients
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo
Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma
Dormann, C
Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver
Dow, LE
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Drasdo, D
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
Drebber, U
Lipid droplets and associated proteins in viral hepatitis
Drenth, JPH
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Dries, V
Lipid droplets and associated proteins in viral hepatitis
Dröge, C
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
Dropmann, A
Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver
Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma
Drucker, E
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
Dudek, M
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
Duong, S
Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
Durantel, D
Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
Duret, D
Steatosis and associated proteins in hepatocellular adenoma
Ebert, MP
Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer
How endoglin modulates the hepatocytes' response to BMP-9
Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Characterization of the liver phenotype of the BMP-9 knock-out mouse
Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo
Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma
PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma
Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
Ehlken, H
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Ehlting, C
Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β
Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3
Ehmer, U
A targeted screen to identify relevant oncogenes in RAS activated liver cancer
Ehrenmann, P
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Ehrlich, S
Type I Interferons promote maintenance and function of follicular T helper cells in vitro
Eischeid-Scholz, H
Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells
Eiteneuer, E
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
Elshaarawy, O
Liver stiffness decreases in response to portal pressure lowering drugs
Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development
Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis
Critical flicker frequency improves after alcohol abstinence
Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Emmerich, F
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
Endris, V
RSPO2 gene rearrangement – a new cancer driver in the liver
Erdem, M
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
Erlangga, Z
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Ernst, I
Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
Essler, M
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
Estévez Vázquez, O
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Evert, K
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
Evert, M
Hepamine 2.0
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Eyer, F
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Falk, CS
Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
Fan, W
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Fatima, S
Investigation of hepatic and renal toxicity induced by omeprazole in CCl4 injury mouse model
Fauvelle, C
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Feder, S
Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration
Felden, J von
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Felkel, C
Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
Feng, R
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Ferreirós, N
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Fichtner-Feigl, S
Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
Figura, G von
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice
Finkelmeier, F
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Finnemann, C
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Fischer, HP
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
Fischer, J
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Fischer, MMJ
Lysophosphatidic acid activates peripheral glial cells
Fischer, P
Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
Fischer, S
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Fitting, D
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Flecken, T
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Florian, R
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
Forman, LM
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Fragoulis, A
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
Franck, S
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Frank, A
Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)
Franke, A
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Freese, K
Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes
Pregnancy-associated plasma protein-A as potential novel target and serum marker for hepatic fibrosis
Variation of the expression of different Histone deacetylases (HDACs) and the functional effects of HDAC-inhibitors in hepatocellular carcinoma
Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma
Fricker, G
Delivery of Copper-chelating Trientine (TETA) to the central nervous system
Friess, H
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice
Frishman, D
Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
HDVdb: Hepatitis D virus database
Frissen, M
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Fritz, V
The potent modulator of cholesterol biosynthesis insulin-induced gene 1 (INSIG1) is a novel hypoxia-regulated tumor suppressor in hepatocellular carcinoma
Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma
Fromme, M
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Gaestel, M
Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3
Gagliani, N
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Gaitantzi, H
How endoglin modulates the hepatocytes' response to BMP-9
Characterization of the liver phenotype of the BMP-9 knock-out mouse
Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma
Gajowski, R
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
Gal, FL
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
Gallage, S
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Gallati, S
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Galle, PR
Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Galvez, EJC
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Gandraß, M
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Gan-Schreier, H
iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet
Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism
Liver specific-deletion of FATP4 increases hepatic triglycerides upon D8-glycerol administration: a stable isotope labelling study
iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes
Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress
Gänssler, JM
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
Ganzha, A
iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes
Gargani, S
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Gasparoni, G
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Gassler, N
Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury
Gaßner, J
Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
Gavaghan, M
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Gawaz, M
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Gaza, A
Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma
Gebhardt, L
Lysophosphatidic acid activates peripheral glial cells
Gebhardt, R
The interactions of Hedgehog and mTor signaling in Hepatocytes
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
Geffers, R
The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
Gehrke, N
Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)
Geier, A
Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression
Suppression of bile acid-CoA:amino acid N-acyltransferase gene expression by the interleukin-6-type cytokine Oncostatin M
The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)
Geisslinger, G
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Genesca, J
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Gerardy-Schahn, R
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Gerbes, AL
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Gerken, G
Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients
Characteristics and outcome of 544 patients with autoimmune hepatitis (AIH) – a single centre experience
Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease
Gertzen, C
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
Ghallab, A
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Ghamarnejad, O
Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma
The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy
GhamarNejad, O
Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy
Ghamar Nejad, O
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
Ghennam, E
The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?
Giersch, K
The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Giesler, M
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Gillich, N
Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
Glebe, D
Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
Gluud, LL
The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis
Goeppert, B
Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
Goeser, F
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Goeser, T
The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?
No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany
Goetze, O
Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)
Gohlke, H
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
Golriz, M
Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma
Goltz, D
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
Gordan, J
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Gordien, E
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
Görg, B
Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis
Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia
Gostick, E
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Gotter, C
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Gottfried-Brand, D
Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
Gotthardt, D
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival
Götze, O
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Gould, K
Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Gozdowska, J
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Grandt, D
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Grandt, J
The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis
Greinert, R
Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten
Gremse, F
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
Gretz, N
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Grevelding, CG
Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten
Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell
Grewe, I
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Griffiths, WJH
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Grimminger, P
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Groth, S
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Grove, J
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Grünhage, F
Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene
Grzybek, M
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Gschwendter, H
Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma
Gschwendtner, H
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis
Gu, Z
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Guenther, V
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Guha, IN
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Guldiken, N
In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Gülow, K
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?
Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion
Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma
Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis
Gunda, M
Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels
Guo, F
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Gürlevik, E
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
Guthke, R
Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation
Guttmann, S
SERPINA1 levels dictate TTR expression in HepG2 cells
Haas, U
LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses
Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells
Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression
Haberl, EM
Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration
Haderer, M
Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis
Hagel, C
Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose
Haifeng, X
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Hall, RA
Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene
Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
Haller, D
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Hamesch, K
In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Hammad, S
Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration
Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
Aged Abcb4-/- mice upon acute sublethal chemical insult recapitulate features of acute-on-chronic liver failure in patients
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo
Hampe, J
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Loss of zonation in end stage liver disease revealed by in situ omics
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis
Han, M
Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo
Hanenberg, H
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
Hardtke, S
Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
Harris, R
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Harten, M von
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Hartl, J
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose
Hartmann, D
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice
Hartmann, H
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Hartmann, M
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Hartmann, N
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Hartwig, V
Simultaneous isolation of parenchymal and non-parenchymal cells from healthy and diseased mice liver
Hassan, R
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Hatting, M
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Haupts, A
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Häussinger, D
Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression
Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β
Deletion of thrombin receptor PAR4 attenuates the development of insulin resistance and NAFLD in mouse fed high-fat diet
Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage
Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis
Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3
Hepatocytes induces properties of wound healing type and regulatory macrophages in co-cultivated BMDM
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Haybaeck, J
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Healy, M
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Heeren, J
LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Heide, D
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Heikenwälder, M
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Heilmann-Heimbach, S
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Heim, K
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Heimes, CV
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Heine, K
Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses
Heinold, A
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Heinrich, F
The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis
The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells
Heinrich, S
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Steatosis and associated proteins in hepatocellular adenoma
Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma
Heinrichs, D
Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
Heinsen, FA
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Heintz, L
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study
Heinzow, H
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Hellerbrand, C
Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes
Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes
Pregnancy-associated plasma protein-A as potential novel target and serum marker for hepatic fibrosis
The potent modulator of cholesterol biosynthesis insulin-induced gene 1 (INSIG1) is a novel hypoxia-regulated tumor suppressor in hepatocellular carcinoma
Variation of the expression of different Histone deacetylases (HDACs) and the functional effects of HDAC-inhibitors in hepatocellular carcinoma
Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma
Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma
Helm, F
Delivery of Copper-chelating Trientine (TETA) to the central nervous system
Hempel, M
Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
Hendricks, L
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Hengstler, JG
Jagged-1 upregulation in stressed hepatocytes is crucial for liver regeneration
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
Aged Abcb4-/- mice upon acute sublethal chemical insult recapitulate features of acute-on-chronic liver failure in patients
Hennings, J
Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
Hensel, N
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Herkel, J
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
Hermanns, HM
Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression
Suppression of bile acid-CoA:amino acid N-acyltransferase gene expression by the interleukin-6-type cytokine Oncostatin M
Hermanussen, L
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Herpel, E
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
Herrera Gonzalez, BM
Characterization of the liver phenotype of the BMP-9 knock-out mouse
Herrmann, A
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Heyne, R
Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Hinrichsen, H
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Hippchen, T
The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis
Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort
Hochrath, K
Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene
Hoffmann, D
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Hoffmann, K
Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma
Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
Hoffmeister, C
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Hofmann, M
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Type I Interferons promote maintenance and function of follicular T helper cells in vitro
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
Hofmann, U
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Hofmann, WP
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Hohenester, S
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
Höhme, S
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
Holland, C
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
Holz, R
Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study
Holzer, K
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
Hooiveld, GJ
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Hoppmann, H
TIPS placed before current hospitalization and early admission to ICU increase survival of patients with cirrhosis and sepsis
Horner, R
Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
Horst, AK
Dissecting cell-specific CEACAM1 expression on immune cells in hepatic immune regulation
Horst, D
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
Hou, J
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Howe, T
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Hsu, MJ
Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids
Hu, X
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Huang, J
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Hübbers, A
Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells
Huber, M
Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen
Huber, S
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice
Huber, Y
Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)
Hueser, N
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Hüser, N
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice
Ibidapo-obe, O
Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis
Imiela, CS
Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen
Ingiliz, P
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Inverso, D
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Irungbam, K
CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice
Ishaque, N
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Itzel, T
Hepamine 2.0
Jacobi, F
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Jacobs, S
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Jäger, M
Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis
Jakubowski, S
Steatosis and associated proteins in hepatocellular adenoma
Janciauskiene, S
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Jankowska, I
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Jankowski, K
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Jansen, C
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Janssen, H
Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
Ji, J
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
Jia, J
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Jin, Y
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Jöchle, K
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
John, C
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Jordan, S
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Jördens, MS
Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis
Jud, A
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
Jumpertz, S
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
Jung, J
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Junger, H
Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation
Junghanss, T
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
Kaderali, L
Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma
Kah, J
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Kahraman, A
Intravenous therapy of hepatic encephalopathy with L-ornithine l-aspartate (Lola) is safe and very effective
Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients
Characteristics and outcome of 544 patients with autoimmune hepatitis (AIH) – a single centre experience
Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease
Kaiser, K
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Kalkhof, S
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
Kallin, N
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver
Kamlage, B
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Kanitz, V
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Kantowski, M
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Karagoz, E
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
Karatayli, E
Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
Karatayli, SC
Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
Karimzadeh, H
Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
HDVdb: Hepatitis D virus database
Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Karsdal, M
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Kasper, P
No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany
Kather, JN
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Kattler, K
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Kauer, L
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Kaufmann, B
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice
Keitel, V
Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage
Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Kellerer, M
Dissecting cell-specific CEACAM1 expression on immune cells in hepatic immune regulation
Kemming, J
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Kemper, T
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Kern, L
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Kersting, S
Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease
Khajeh, E
Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma
Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy
Kickuth, R
Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)
Kiessling, F
Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing
Kim, P
Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Kimer, N
The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis
Kiraithe, M
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Kircher, M
Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)
Kirchner, M
Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
Klausen, G
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Kleeschulte, S
Deletion of thrombin receptor PAR4 attenuates the development of insulin resistance and NAFLD in mouse fed high-fat diet
Klein, I
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Klein, R
Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)
Klingmüller, U
Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
Klinker, H
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Klopp, A
Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells
Klöters-Plachky, P
Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis
Klotz, S
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Kluge, M
Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
Kluwe, J
LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis
Knight, A
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Knolle, PA
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver
Identification of the unique functional phenotype of iMATE-defining monocytes that drive hepatic T cell proliferation
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver
Ko, C
Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
Koch, A
Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes
Koch, M
Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening
Koczulla, R
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Kohlhepp, M
Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression
Köhncke, J
Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
Kohnke-Ertel, B
A targeted screen to identify relevant oncogenes in RAS activated liver cancer
Kolbe, E
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
König, V
Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
Kontoyiannis, D
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Kook, L
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
Koop, A
LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis
Korte, I
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Koschny, R
Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival
Köse, N
Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis
Kotsiliti, E
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Krabbe, V
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Kraft, ARM
Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B
Krag, A
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Krämer, B
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Kratochvil, I
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
Krawczak, M
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Krawczyk, M
The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort
Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Kremer, AE
Lysophosphatidic acid activates peripheral glial cells
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
Kriegsmann, M
RSPO2 gene rearrangement – a new cancer driver in the liver
Kristiansen, G
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
Kriz, M
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Kroy, DC
Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression
Krstic, T
The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice
Kubes, P
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Kubicka, S
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
Kücükoglu, Ö
Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten
Kudlich, T
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Kueppers, A
Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Kuhn, M
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Kühn, H
Lysophosphatidic acid activates peripheral glial cells
Kühne, H
Physical contact between mesenchymal stromal cells and hepatocytes via tunneling nanotubes favor the utilization of hepatocyte lipids
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
Kühnel, F
Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
Kummer, U
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
Kunst, C
Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?
Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma
Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis
Kunzmann, L
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Kurz, S
Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
Kütting, F
No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany
Lam, M
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
Lambertz, D
Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells
Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression
Lammers, T
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
Lammert, F
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort
Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten
Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle
Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene
Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Lam Wai-Ling, M
Hepatic Progenitor Cells/Oval Cells Mediate Pro-inflammatory Responses upon Liver Injuries
Lan, S
Critical flicker frequency improves after alcohol abstinence
Lang, A
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
Lang, H
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Lang, J
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Lang, KS
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Lang, P
Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage
Lang, PA
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Lang, S
No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany
Lang, SA
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
Lange, C
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
Lange, CM
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Langholm, L
Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis
Langlotz, M
Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress
Lapa, C
Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)
Laschinger, M
The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver
Laschtowitz, A
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose
Laszik, Z
Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation
Lattanzi, B
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Latz, E
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Lebensztejn, D
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Lechler, C
A targeted screen to identify relevant oncogenes in RAS activated liver cancer
Lederer, P
Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression
Lederle, W
Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing
Lee, S
Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes
Lee, SH
Effect of selective internal radiation therapy (SIRT) in patients with unresectable primary or metastatic liver tumors on microsomal liver function by means of 13C-methacetin breath test (MBT)
Lee, SML
Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes
Leeming, D
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Lehmann, J
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Lehmann, R
The interactions of Hedgehog and mTor signaling in Hepatocytes
Lelouvier, B
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Lempp, FA
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
Leone, V
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Lerch, MM
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Lesche, M
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Levy, M
Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
Li, H
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Li, X
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Liao, L
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Liberman, A
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Lichtenberger, J
Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten
Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell
Lickei, H
Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
Liebe, R
Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten
Liebig, S
Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis
Liebisch, G
iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes
Liedtke, C
Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression
Lieshout, R
Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening
Lin, T
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Liu, C
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Liu, K
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Liu, T
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Liwinski, T
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose
Llewelly-Laceys, S
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
Llovet, JM
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Loeffler, MA
Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
Löhr, J
Thrombelastometry in patients with acute-on-chronic liver failure
Lohse, AW
The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice
LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Longerich, T
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
RSPO2 gene rearrangement – a new cancer driver in the liver
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Lotter, H
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Lu, K
Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia
Lu, M
The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Lucifora, J
Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
Lücke, K
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Ludwig-Portugall, I
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Luedde, T
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Luis, ZRL
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Luo, X
The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells
Lurje, G
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
Lütgehetmann, M
The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Lüth, S
Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa
Lütjohann, D
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Lutz, P
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Luxenburger, H
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Maasoumy, B
Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
MacConell, L
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Macheleidt, I
Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma
Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
Macpherson, A
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Madsen, BS
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Magdaleno, F
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Mahli, A
Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes
Mahn, F
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Maiju, M
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Main, N
Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
Majlesara, A
The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy
Malehmir, M
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Malo, A
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Mandorfer, M
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Manekeller, S
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Manka, P
Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
Manmadhan, S
A targeted screen to identify relevant oncogenes in RAS activated liver cancer
Manns, MP
Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis
Functional microRNA screening to improve hepatocyte formation via direct reprogramming
Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Manon-Jensen, T
Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis
Manske, K
Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver
Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver
Marhenke, S
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Markovic, J
Functional microRNA screening to improve hepatocyte formation via direct reprogramming
Marquardt, J
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma
Marquardt, JU
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Marschall, HU
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Martin, A
No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany
Marx, A
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Matteo, M
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Matthias, E
Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose
Matz-Soja, M
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
The interactions of Hedgehog and mTor signaling in Hepatocytes
Loss of zonation in end stage liver disease revealed by in situ omics
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
Mayerle, J
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Mayr, D
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
McKenna, SJ
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
McQuillin, A
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Mehrabi, A
RSPO2 gene rearrangement – a new cancer driver in the liver
Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma
Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy
Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy
Meierhofer, D
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
Meindl-Beinker, NM
Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Melter, M
Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC
Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation
Menzel, M
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
Merle, U
Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism
Thrombelastometry in patients with acute-on-chronic liver failure
Merli, M
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Mertens, A
Effects of SNPs in HE-relevant genes on the development of hepatic encephalopathy in patients with liver cirrhosis
Messerschmidt, I
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Mester, PI
Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma
Metzendorf, C
Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)
Hepatocellular clear cell foci in ChREBP knockout and wild type mice after intraportal pancreatic islet transplantation – a long time experiment
Meyer, C
Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer
Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma
Micali, G
Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
Michael, T
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Michaelis, J
Thrombelastometry in patients with acute-on-chronic liver failure
Michalski, M
Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion
Michels, B
TIPS placed before current hospitalization and early admission to ICU increase survival of patients with cirrhosis and sepsis
Michler, T
Estimation of the genotype distribution within global chronic hepatitis B virus infections
Mijočević, H
Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
Milkiewicz, M
Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene
Milkiewicz, P
Quantitative trait analysis in Abcb4 deficient mice identifies Pcks9 as a potential modifier gene
Ming, T
Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma
Ming, Y
iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet
Miravitlles, M
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Mirtschink, P
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Mitroulis, I
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Mittrücker, HW
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Mix, C
Impact of HBsAg on HBV-specific immune responses in HBeAg negative patients with chronic hepatitis B
Möbus, S
Functional microRNA screening to improve hepatocyte formation via direct reprogramming
Möckel, D
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
Moeller, LS
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Mogler, C
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice
Mohamed, MR
Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury
Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice
Mohammadikhajehdehi, S
Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma
Mohs, A
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression
Möller, S
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Mondorf, A
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Monga, SP
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
Moolenaar, W
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Moosburner, S
Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
Morgan, MY
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Morgül, H
Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching
Moser, V
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Muche, M
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Mücke, MM
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Muders, M
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Mueller, J
Liver stiffness decreases in response to portal pressure lowering drugs
Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development
Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis
Critical flicker frequency improves after alcohol abstinence
Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Mueller, S
Liver stiffness decreases in response to portal pressure lowering drugs
Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development
Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Critical flicker frequency improves after alcohol abstinence
Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Müller, M
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Müller-Schilling, M
Delirium – of outstanding relevance for the interprofessional team on an intensive care unit with focus on hepatology
TIPS placed before current hospitalization and early admission to ICU increase survival of patients with cirrhosis and sepsis
Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?
Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion
Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma
Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis
Mutz, P
The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver
Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
Møller, S
The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis
Nahon, P
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Nassal, M
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Nati, M
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Nattermann, J
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Naumann, U
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Neeff, HP
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
Nehring, S
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Neuber, S
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Neuhaus, K
Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
Neumann, A
The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Neumann, K
The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis
The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice
Neumann, O
RSPO2 gene rearrangement – a new cancer driver in the liver
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Neumann-Haefelin, C
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
Neuwirth, A
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
Nevzorova, YA
Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury
Ni, Y
IFN response suppresses HDV persistence during hepatocytes proliferation in vitro
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Nickkholgh, A
Liver Resection for Cholangiocarcinoma: Biological and Surgical Predictors of Outcome, Status Quo in Additive Therapy
Nicklas, A
Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle
Nielsen, MJ
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Niemann, J
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Niemietz, C
SERPINA1 levels dictate TTR expression in HepG2 cells
Nierhoff, D
The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?
Nieswandt, B
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Niewiadomska, O
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Nikdad, M
Meta-analysis of the efficacy of preoperative biliary drainage in hilar cholangiocarcinoma
Nimanong, S
Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
Nischalke, HD
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Nkongolo, S
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
Nordheim, A
The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
Nordström, K
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Nürnberger, V
Hepatocellular clear cell foci in ChREBP knockout and wild type mice after intraportal pancreatic islet transplantation – a long time experiment
Nwosu, ZC
Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer
Liver cell type specific discrimination of TGF-beta signaling and outcome in vitro and in vivo
PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma
O'Connor, T
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
O'Rourke, C
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Oberhardt, V
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Ochel, A
The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis
The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells
Ocker, M
CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice
Odenthal, M
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma
Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells
Oleksiuk, O
Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
Oppermann, H
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
Ori, A
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
Ostroumov, D
Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
Othman, A
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
Ott, F
The interactions of Hedgehog and mTor signaling in Hepatocytes
Ott, JJ
Estimation of the genotype distribution within global chronic hepatitis B virus infections
Ott, M
Functional microRNA screening to improve hepatocyte formation via direct reprogramming
Otto, AC
iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes
Oude Elferink, R
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
Padem, S
Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten
Palladini, A
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Pampaloni, F
Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening
Pandyra, AA
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Pannicke, N
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Panning, M
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Pape, UF
Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching
Parés, A
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Park, YN
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Parsberg Werge, M
The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis
Pascher, A
Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching
Paukstat, K
The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort
Paul, A
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Paul, D
Identification of host cell factors involved in hepatitis C virus replication
Role of autophagy in hepatitis C virus replication
Pavel, M
Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching
Pawelka, K
Identification of the unique functional phenotype of iMATE-defining monocytes that drive hepatic T cell proliferation
Pawella, LM
Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
Pearce, EL
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Peccerella, T
Liver stiffness decreases in response to portal pressure lowering drugs
Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis
Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers
Pecerella, T
Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development
Peiseler, M
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Pellegrino, R
The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Pencek, R
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Peng, J
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Pereira, S
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Pereira, V
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Peuker, K
Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis
Pfaff, L
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Pfeffer, K
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Pfefferkorn, M
Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
Pfister, D
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
Philip, B
Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells
Philippski, P
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
Pichlmair, A
Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses
Piecha, F
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose
Piekorz, R
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
Pieper, C
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Pigliacelli, A
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Piiper, A
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Pikarsky, E
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Pinna, F
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Pinter, M
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Pinyol, R
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Pioronska, W
Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer
PRRX1 cooperate with ZEB1/ZEB2 in hepatocellular carcinoma
Pischke, S
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa
Pleli, T
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Poch, T
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Pockros, PJ
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Pohl, J
Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
Pohl, R
Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration
Pohlmann, A
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Pollinger, K
Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?
Induction of cell death in hepatocellular carcinoma (HCC) via energy depletion
Impact of new targeted therapies on the regulation of p53-family and cell death behavior of hepatoma cells in hepatocellular carcinoma
Polz, R
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Pons, M
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Poplawski, A
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Poppenborg, F
Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle
Poth, T
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Praktiknjo, M
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Pratschke, J
Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching
Preti, M
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Preuß, B
Serologische Differenzierung zwischen alkoholischer Lebererkrankung (ALD) und nicht-alkoholischer Fettlebererkrankung (NAFLD) anhand des Nachweises von IgA-Antikörpern gegen Alkoholdehydrogenase (ADH)
Price, DA
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
Prinz, M
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Prokosch, S
Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
Protzer, U
HDVdb: Hepatitis D virus database
Estimation of the genotype distribution within global chronic hepatitis B virus infections
Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells
Przybysz, R
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Puchas, P
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Pulé, M
Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells
Pusch, S
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
Qiao, Y
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
Quack, T
Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten
Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell
Queck, A
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
Quickert, S
Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience
Raabe, J
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Rad, R
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Rahbari, N
Pro- and anti-tumourigenic effects of Bone morphogenetic protein 9 signaling in hepatocellular carcinoma
Ramadori, P
Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Rappez, L
Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism
Raschzok, N
Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
Rasech, S
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Rasenack, J
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Rath, D
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Ratziu, V
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Rau, M
The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Rausch, V
Liver stiffness decreases in response to portal pressure lowering drugs
Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development
Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis
Critical flicker frequency improves after alcohol abstinence
Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels
Ravichandran, G
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice
Raziorrouh, B
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Real, CI
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Recklinghausen, I von
Cellular and nuclear hepatocyte ploidy represent a repository in regenerating livers
Regel, I
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Rehman, A
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Reich, M
Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage
Role of the bile acid receptor TGR5 (GPBAR1) in cholangiocarcinoma (CCA)
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Reichel, F
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Reichert, AS
Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia
Reichert, MC
Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten
Reike-Kunze, M
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Rein-Fischboeck, L
Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration
Reisinger, F
Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
Reißing, J
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Reiter, FP
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Rempel, E
RSPO2 gene rearrangement – a new cancer driver in the liver
Reuken, P
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Reuken, PA
Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience
Reuter, A
Activation of the interferon response by HCV is mediated by MDA5 and potentiated by LGP2
Ribback, S
Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)
Hepatocellular clear cell foci in ChREBP knockout and wild type mice after intraportal pancreatic islet transplantation – a long time experiment
Rickert, A
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Ridder, DA
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma
Riedl, T
Mechanisms of Lymphotoxin-beta Receptor Agonization induced upregulation of the anti-HBV host restriction factor APOBEC3B
Riepl, J
Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC
Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation
Rinella, M
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Ripoll, C
Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten
Rißel, M
Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
Ritz, TP
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
Robering, J
Lysophosphatidic acid activates peripheral glial cells
Röcken, C
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Loss of zonation in end stage liver disease revealed by in situ omics
Rockstroh, J
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Röder, C
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Roderburg, C
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Roderfeld, M
Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression
CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice
Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten
Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen
Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell
Rodríguez-Frías, F
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Roeb, E
Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression
CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice
Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Ausschalten der Typ I Interferonantwort führt zu verminderter Induktion von Autophagie in HBs transgenen Mäusen
Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell
Roessler, S
Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
Roggendorf, M
Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
HDVdb: Hepatitis D virus database
Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Rösch, T
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Rose, M
Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience
Rose-John, S
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Rosen, D
The journey of a patient with biopsy-proven non-alcoholic steatohepatitis (NASH) – results from a real-world study
Rosenblatt, M
Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction
Rosendahl, J
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Rosenwald, A
RSPO2 gene rearrangement – a new cancer driver in the liver
Rösner, T
A targeted screen to identify relevant oncogenes in RAS activated liver cancer
Rössle, M
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Rössler, S
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Roth, W
Lipid droplets and associated proteins in viral hepatitis
Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Steatosis and associated proteins in hepatocellular adenoma
Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma
Roy, S
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Ruf, J
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
Rufinatscha, K
Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β
Rühlemann, MC
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Rupp, C
The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis
Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort
Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis
Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival
Rüschenbaum, S
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Ryan, E
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Ryan, P
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Ryder, S
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Sabagh, M
The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy
Saborowski, A
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Saborowski, M
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Saez-Rodriguez, J
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
Sage, J
A targeted screen to identify relevant oncogenes in RAS activated liver cancer
Sahin, H
Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Sakin, V
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
Salimi Alizei, E
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Sànchez Munoz, A
Characterization of the liver phenotype of the BMP-9 knock-out mouse
Sandfort, V
SERPINA1 levels dictate TTR expression in HepG2 cells
Sauer, IM
Are preoperative laboratory parameters predictive for the metabolic function of primary human hepatocytes?
Sauer, P
Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis
Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival
Sauerbruch, T
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Schaarschmidt, V
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Schachschal, G
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Schäfer, J
Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
Schafmayer, C
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Loss of zonation in end stage liver disease revealed by in situ omics
Schakat, M
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
Schattenberg, JM
Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)
Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Schatz, P
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Schelbert, S
Lipid droplets and associated proteins in viral hepatitis
Scheller, J
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Scherm, S
Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
Schierwagen, R
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Schilcher, K
Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC
Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation
Schiller, F
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
Schilling, M
Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction
Schindeldecker, M
Lipid droplets and associated proteins in viral hepatitis
Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma
Schirmacher, P
Lipid droplets and associated proteins in viral hepatitis
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
RSPO2 gene rearrangement – a new cancer driver in the liver
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Schlaak, J
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Schlattjan, M
Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten
Schlitt, HJ
Induction of biliary epithelial wound healing and angiogenesis through IL6 in donor bile ducts after liver transplantation
Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
Schlosser, S
Innovative biomarkers detecting spontaneous bacterial peritonitis in ascitic fluid of liver cirrhosis patients
Reduced mucus layer and destabilized epithelial barrier – are these the first triggers driving spontaneous bacterial peritonitis?
Proliferation, migration and cell viability in hepatocellular carcinoma – what is the impact of IGFBP2?
Schlue, J
Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis
Schmid, RM
A targeted screen to identify relevant oncogenes in RAS activated liver cancer
Schmid, S
Delirium – of outstanding relevance for the interprofessional team on an intensive care unit with focus on hepatology
TIPS placed before current hospitalization and early admission to ICU increase survival of patients with cirrhosis and sepsis
Schmidt, A
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Schmidt, H
SERPINA1 levels dictate TTR expression in HepG2 cells
Schmidt-Arras, D
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Schmiel, M
Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma
Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells
Schmithals, C
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Schmitt, J
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Schmitt, V
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Schmitt-Graeff, A
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
Schneider, A
Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver
Schneider, C
Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten
Schneider, KM
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Schneller, D
Hepatic Progenitor Cells/Oval Cells Mediate Pro-inflammatory Responses upon Liver Injuries
Schnieders, A
Characterization of immune cells in patients with liver cirrhosis with and without spontaneous bacterial peritonitis
Schnitzler, P
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
Schocknecht, T
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Scholtis, A
Recognition of bacteria by intestinal epithelial cells and regulation of p53 signaling and cell death – interactions at the epithelial interface leading to spontaneous bacterial peritonitis in liver cirrhosis
Schöneweis, K
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Schönfels, W von
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Loss of zonation in end stage liver disease revealed by in situ omics
Schott, T
Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
Schramm, C
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose
Schubert, K
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
Schubert, L
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Schuch, A
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Schulte, S
The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?
Schultheiss, M
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Schulz, L
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Schulze, F
RSPO2 gene rearrangement – a new cancer driver in the liver
Schulze-Osthoff, K
Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis
Schulze-Pellengahr, S
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Schulze zur Wiesch, J
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Schumacher, N
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Schwarze-Zander, C
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Schwarzkopf, K
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
Schwarzkopf, KM
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Schweinoch, D
Tackling the HCV Life Cycle with Mathematical Modeling – Decoding the Enigma
Schwenzer, J
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Schwinge, D
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice
Schwittai, I
Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
Sebastian, M
Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels
Sebode, M
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose
Seddek, A
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Seebach, J
Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
Seehawer, M
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Seehofer, D
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Seeßle, J
Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism
Thrombelastometry in patients with acute-on-chronic liver failure
Seitz, HK
Liver stiffness decreases in response to portal pressure lowering drugs
Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development
Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis
Critical flicker frequency improves after alcohol abstinence
Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers
Seitz, T
Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma
Seufferlein, T
Der Einsatz einer permanenten Aszitesdrainage bei Patienten mit therapierefraktärem Aszites bei Peritonealkarzinose und end-stage-Leberzirrhose: Vergleich des Komplikationen- und Sicherheitsprofils
Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose
Shackel, N
Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
Shafiei, S
The effect of Pringle maneuver in surgical outcome in patients underwent extended hepatectomy
Shang, R
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Shao, C
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Sharma, AD
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Functional microRNA screening to improve hepatocyte formation via direct reprogramming
Sharma, R
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Sheikh, N
Evaluation of hepatoprotective potential of Itraconazole in CCl4 induced liver injury mouse model
Investigation of hepatic and renal toxicity induced by omeprazole in CCl4 injury mouse model
Silva, I
Liver stiffness decreases in response to portal pressure lowering drugs
Role of PNPLA3 rs738409 and MBOAT7 rs626283 during alcohol detoxification: Indication of different mechanisms for fibrosis development
Response of spleen stiffness to portal pressure lowering drugs in a rat model of cirrhosis
Obesity negatively affects LS and CAP resolution after alcohol detoxification in heavy drinkers
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels
Simon, KG
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Simon, P
Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)
Singer, S
Protumorigenic stathmin expression in liver cancer is linked to karyopherin alpha 2-dependent import of E2F1 and TFDP1
Singh, I
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Sinha, A
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Smedile, A
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Smits, M
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Type I Interferons promote maintenance and function of follicular T helper cells in vitro
Socha, P
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Soehnlein, O
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
Sollors, J
Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
Sommer, J
Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes
Song, X
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Sonntag, R
Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells
Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression
Sörensen, A
Comparing 99mTc-mebrofenin scintigraphy and LiMAx-Test to assess presurgical functional liver capacitiy before major liver resection
Sowa, JP
Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten
Spengler, U
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Spielberg, S
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Spirk, M
Chemerin-156 reduces liver tumor growth in vivo but has no effect on liver cell proliferation and migration
Spitzley, S
Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression
Spivak, I
In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Spormann, L
The interactions of Hedgehog and mTor signaling in Hepatocytes
Springer, J
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
Stadler, M
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism
Stallmach, A
Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis
Hepatitis E is a frequent cause of severe acute liver injury – a tertiary referral center experience
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Stancu, O
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Stefanescu, H
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Steffen, HM
The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?
No significant impact of HCC surveillance on overall mortality – data from a tertiary referral center in Germany
Steiger, K
Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
A targeted screen to identify relevant oncogenes in RAS activated liver cancer
Stein, K
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Stein, S
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Steinebrunner, N
Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
Stellmacher, F
Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Stengel, S
Functional assessment of peritoneal mucosal associated invariant T (MAIT) cells in advanced cirrhosis
The ATG16L1 Gene Variant rs2241880 (p.T300A) Is Associated With Susceptibility to HCC In Patients with Cirrhosis
Stenzinger, A
Cholangiocarcinogenesis is a developmental process driven by distinct sequential alterations of the cellular transcriptome
RSPO2 gene rearrangement – a new cancer driver in the liver
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
Stewart, S
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Stickel, F
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Loss of zonation in end stage liver disease revealed by in situ omics
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Stindt, J
Upregulation of TGR5 (Gpbar1) in macrophages protects mice from lipopolysaccharide and Listeria monocytogenes-induced liver damage
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
Stindt, S
Hepatitis C virus inhibits IL-1β-induced IκBζ expression in a Calpain-dependent manner resulting in LCN2 suppression
Hepatitis C Virus mediates induction of CXC chemokine expression in response to the inflammatory cytokines TNFα and IL-1β
Stoehr, A
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Stojkovic, M
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
Stöpel, C
Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
Strand, D
Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
Differential effect of TGF-β family members on proliferation and migration in primary liver cancer
Strand, S
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
Strassburg, CP
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Straub, BK
Voluntary distance running prevents disease progression in mice with non-alcoholic fatty liver disease (NAFLD)
Lipid droplets and associated proteins in viral hepatitis
Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Steatosis and associated proteins in hepatocellular adenoma
RSPO2 gene rearrangement – a new cancer driver in the liver
Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma
Stremmel, W
Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism
Delivery of Copper-chelating Trientine (TETA) to the central nervous system
Strigli, A
Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis
Strnad, P
In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Stroszczynski, C
Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
Strowig, T
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Strücker, B
Minimally invasive versus open hepatic resection for NEN liver metastasis: Case matched study with propensity score matching
Sturm, L
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Su, H
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Subramanian, P
The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Sun, B
ECM1 is a gatekeeper that restrains TGF-β activation to maintain liver homeostasis and prevent fibrogenesis
Sundaram, B
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Superti-Furga, G
Identification of host cell factors involved in hepatitis C virus replication
Sureau, C
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Surewaard, BGJ
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Svetlana, H
Nierenperfusion und -steifigkeit als Marker unterschiedlicher renaler Auswirkungen der Leberzirrhose
Sydor, S
Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Syn, WK
Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
Szydlowska, M
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Tabata, K
Identification of host cell factors involved in hepatitis C virus replication
Role of autophagy in hepatitis C virus replication
Tacke, F
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression
Tao, J
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
Tauber, C
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
Tayyeb, A
Evaluation of hepatoprotective potential of Itraconazole in CCl4 induced liver injury mouse model
Investigation of hepatic and renal toxicity induced by omeprazole in CCl4 injury mouse model
Techritz, N
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Teresa, P
Macrophage-hepatocyte crosstalk modulates hepcidin under physiological oxygen levels
Terracciano, L
Three years of Obeticholic Acid (OCA) Therapy Results in Histological Improvements in Patients with Primary Biliary Cholangitis: Further Analysis of the POISE Biopsy Substudy
Teufel, A
Hepamine 2.0
Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
Teusel, M
Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction
Thangapandi, RV
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Thasler, WE
Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes
Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes
Pregnancy-associated plasma protein-A as potential novel target and serum marker for hepatic fibrosis
Fibroblast Growth Factor 9 is expressed by activated hepatic stellate cells and promotes progression of hepatocellular carcinoma
Thavamani, A
The interaction of Serum Response Factor (SRF) and ETS domain transcription factors regulate the transcription of the MDM 4 oncogene in HCC
Theurl, I
In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Thiele, M
Spleen to liver stiffness ratio significantly differs between ALD and HCV and predicts disease-specific complications
Thimme, R
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Type I Interferons promote maintenance and function of follicular T helper cells in vitro
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Thodou, V
Intravenous therapy of hepatic encephalopathy with L-ornithine l-aspartate (Lola) is safe and very effective
Thomann, S
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Thomas, D
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Thorgeirsson, SS
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Landscape of (epi-)genetic alterations during malignant transformation in liver cancer
Thursz, MR
In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Tiegs, G
The alarmin IL-33 drives a ST2+ Treg-mediated anti-inflammatory immune response during immune-mediated hepatitis
The interleukin-33 pathway protects mice from immune-mediated hepatitis by inducing AREG-expressing ILC2, anti-inflammatory macrophages and regulatory T cells
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice
Dissecting cell-specific CEACAM1 expression on immune cells in hepatic immune regulation
Timm, J
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
Timmer, J
Prediction of Pathway Desensitization by Mathematical Modeling of IFNα Signal Transduction
Toex, U
The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?
Tolkach, Y
Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging
Tóth, M
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Touma, M
Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten
To Vinh, M
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Tran, L
Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
Trauner, M
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Trautwein, C
Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Pharmacological inhibition of cyclin dependent kinase 2 inhibits proliferation and pro-fibrotic features of Hepatic Stellate Cells
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Bei Patienten mit homozygotem Alpha1-Antitrypsinmangel (Pi*ZZ) ist die Substitution von Alpha1-Antitrypsin mit besseren Leberparametern assoziiert
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Interventional targeting of Cyclin E1 during hepatocarcinogenesis limits stem cell traits and hepatic myeloid cell homing and attenuates cancer progression
Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing
Trebicka, J
The CLIF-C AD-score predicts mortality in patients with non-decompensated cirrhosis
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Collagen type IV remodeling gender-specifically predicts mortality in decompensated liver cirrhosis
Presence of sarcopenia is associated with development of acute-on-chronic liver failure in the NEPTUN cohort
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Treckmann, J
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Treitl, M
Varizenblutung oder Aszites: Was bewirkt den Unterschied?
Tremmel, R
Delivery of Copper-chelating Trientine (TETA) to the central nervous system
Trippler, M
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Tschuschner, A
Hepatozelluläre c-Jun Aktivierung durch Schistosoma mansoni Infektion im Hamster Modell und primären humanen Hepatozyten
Tu, T
Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
Tuma-Kellner, S
iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet
Liver specific-deletion of FATP4 increases hepatic triglycerides upon D8-glycerol administration: a stable isotope labelling study
iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes
Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress
Tumanov, AV
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Twu, WI
Role of autophagy in hepatitis C virus replication
Uerlings, R
Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Uhrig, S
RSPO2 gene rearrangement – a new cancer driver in the liver
Unger, K
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Urban, C
Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses
Urban, S
Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
IFN response suppresses HDV persistence during hepatocytes proliferation in vitro
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Uschner, FE
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Usman, Z
Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
HDVdb: Hepatitis D virus database
Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
Utpatel, K
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Vaillant, A
Absence of mutations in the HBsAg “a” determinant during REP 2139 therapy validates serum HBsAg reductions observed in the REP 102 protocol
Mutations in hepatitis B virus surface antigen during therapy with nucleic acid polymer REP 2139-Ca have no influence on treatment outcome or its detection by diagnostic assays
Valenti, L
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
van Bömmel, F
Loss of the middle hepatitis B virus (HBV) surface antigen (MHBs) during interferon-alpha (PEG-IFN) treatment is associated with subsequent lower HBV replication in patients with chronic HBeAg negative hepatitis B
van Bremen, T
Human intrahepatic ILC3 may modulate hepatic stellate cell activation
Van de Leur, E
LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses
van der Kroft, G
An unexpected protective role for macrophages during hepatocellular carcinoma-associated cachexia
van der Laan, L
Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening
Vehreschild, MJGT
Compartmentalization of immune response and microbial translocation in decompensated cirrhosis
Velkov, S
Estimation of the genotype distribution within global chronic hepatitis B virus infections
Verstegen, M
Verification of 3D liver organoids from cholangiocarcinoma tissue for chemotherapeutic drug screening
Vilchez-Vargas, R
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Villa, M
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Vinnemeyer, C
Anti-HEV humoral immunity in long term travellers from Germany to tropical regions in Asia and Africa
Viveiros, A
Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Vlaic, S
Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation
Vogel, A
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Vogel, K
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Voitl, R
The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis
Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort
Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis
Volz, TK
The levels of circulating pgRNA strongly correlate with intrahepatic pgRNA and cccDNA amounts both in HBV mono-infected and in HBV/HDV coinfected humanized mice
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Differential response of culture-derived HDV-1 and HDV-3 strains to peg-IFNα treatment in human liver chimeric mice despite strong ISG induction
Vucur, M
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Wagner-Golbs, A
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Wahlström, A
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Waidmann, O
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Waisman, A
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Walter, J
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Loss of zonation in end stage liver disease revealed by in situ omics
Wammers, M
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
Wan, S
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Wandrer, F
Senescence of T-Cells Increases with Fibrosis Progression in Chronic Viral Hepatitis
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Wandt, N
Cholangiozyten haben eine phagozytische Funktion und zeigen darunter erhöhte metabolische Aktivität und Proliferationsraten
Wang, B
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice
Wang, J
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
Wang, L
Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma
Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells
Wang, P
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Wang, S
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Ware, CF
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Weber, A
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
Weber, SN
Hepatische Abcg5/g8-Defizienz führt zu erhöhten Cholesterinspiegeln in der Galle
Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
Liver fibrosis in conjunction with the prosteatotic PNPLA3 variant affects quality of life in patients with NAFLD: prospective liver stiffness-based study
Weber, T
Endocystectomy technique for surgical treatment of hepatic cystic echinococcosis
Weber, TF
RSPO2 gene rearrangement – a new cancer driver in the liver
Wedemeyer, H
Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
The Hippo signalling is induced by Toll-like receptor 4 activation and regulatory balance innate immune responses in liver cells
Viral escape contributes to the failure of hepatitis D virus (HDV)-specific CD8+ T cells and drives population-level evolution of HDV
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Factors positively correlated with HBs seroconversion in chronic hepatitis B – a single center experience in a German cohort of 387 patients
Analysis of liver biopsies reveals a strong intrahepatic reduction of HDV and inflammatory markers after treatment with Myrcludex B in combination with Tenofovir in chronic HBV/HDV infected patients
Wehmeyer, MH
Retherapie von Patienten mit chronischer Hepatitis-C Infektion nach Versagen einer Behandlung mit direct-acting agents (DAA)
Erste Erfahrung mit dem pangenotypischen Therapieregime Glecaprevir/Pibrentasvir (Maviret) zur Behandlung einer chronischen Hepatitis C Infektion
Krankheitsverständnis und Lebensqualität von Patienten mit chronischer Hepatitis B (HBV) Infektion mit und ohne antivirale Therapie
Wei, X
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
Weidemann, S
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Interferon-γ-dependent immune responses contribute to the pathogenesis of primary sclerosing cholangitis in mice
Weigert, A
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Weiler, SE
Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
Weiler, SME
TAZ-inactivation partly compensates the phenotype caused by YAP knockdown in livers of YAP/TAZ-deficient mice
Weiler-Normann, C
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose
Weinmann, A
Lipid droplets and associated proteins in viral hepatitis
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Clinocopathologic correlation of alpha fetoprotein-expression in situ with serum levels in a large cohort of patients with hepatocellular carcinoma
Weiskirchen, R
LCN2 null mice are sensitive to endoplasmic reticulum stress and unfolded protein responses
Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Weiskirchen, S
Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Weiss, J
A simple clinical score to predict survival in patients with hepatocellular carcinoma
Weiss, KH
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis
Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort
RSPO2 gene rearrangement – a new cancer driver in the liver
Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are markers for biliary damage and predict graft survival
An alternative model for prediction of transplant-free survival in patients with implantation of transjugular intrahepatic portosystemic shunt (TIPS): The Freiburg risk score
Weiss, TS
Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC
Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation
Welsch, C
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Welsch, H
Reshaping of the cellular signaling landscape under continuous stimulation of innate antiviral responses
Weng, HL
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Wenning, C
Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
Werner, M
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Wettengel, J
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Widera, M
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
Wiecek, S
Common variant p.D19 H of the hepatobiliary sterol transporter ABCG5/8 increases the gallstone risk and affects cholesterol homeostasis in children
Wiek, C
A Novel, Cell-Based Assay Allows Direct Measurement of Bile Salt Transport and Serves as Diagnostic Tool for Antibody-Induced BSEP Deficiency (AIBD)
Wieland, D
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Wild, K
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Type I Interferons promote maintenance and function of follicular T helper cells in vitro
Wilhelm, C
Targeting mitochondrial dysfunction can restore antiviral activity of NK cells in HIV/HCV coinfection
Wilhelm, D
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Willuweit, K
Enzymatic liver function measured by LiMAx – a reliable diagnostic tool in chronic liver disease
Wimmer, R
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Accumulating bile salts promote liver fibrosis in cholestasis: in vivo evidence in a mouse model
Wineberger, K
Proteomic analysis of clear cell foci in the human liver identifies differential expression of Starch-Binding Domain-Containing Protein 1 (STBD1)
Wingerath, J
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
Winkler, F
Metabolic programming of exhausted CD8+ T cells in chronic viral hepatitis
Winkler, S
Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
Wirth, TC
Heterologous vaccinations induce potent specific CD8 T-cell immune responses against HCC-expressed tumor-associated antigens
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
Wirtz, TH
Genetic deletion of the chemokine Cxcl10 diminish HCC burden in a murine liver cancer model by modulation of tumor stroma
Novel short-termed mouse model of intrahepatic cholangiocarcinoma (ICC) by orthotopic transplantation of ICC cell line in C57/B6 mice
Wisskirchen, K
T-Cell Receptor Grafting allows Control of Hepatitis B Virus Infection
Evaluation of strategies to increase safety of adoptively transferred HBV-specific T cells
Witt, A
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Underdilation of controlled expansion transjugular intrahepatic portosystemic shunt (TIPS) preserves cardiac function and improves outcome
Witte, V
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
Witzel, HR
Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
Wohlleber, D
Real-time monitoring of HBV-infection in mice revealed antigen level depended outcome of acute and chronic liver infection
Liver damage dampens anti-viral CD8 T cell response by inducing loss of surface T cell receptor expression
Interplay of caspase activation, calcium signaling and decreased mitochondria resilience enables viral clearance in the liver
The pivotal role of target cells in modulating efficacy of antiviral CD8 T cell immunity in the liver
Foxo1-activity controls effector function of CXCR6+CD8+ T cells and prevents liver immune pathology during viral hepatitis and non-alcoholic steatohepatitis
Liver-resident memory CD8+ T cells in chronic viral infection exhibit a unique transcriptional signature and are not terminally exhausted
Development of liver-resident memory CD8+ T cells in acute-resolving and chronic viral infection of the liver
Woitok, MM
Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Hepatocytic c-Jun N-terminal kinases (JNK) protect against cystogenesis in NEMO-deficient mice
Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing
Wolf, K
Lysophosphatidic acid activates peripheral glial cells
Wolf, S
Hepatocytes induces properties of wound healing type and regulatory macrophages in co-cultivated BMDM
Wolff, K
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Wölfl, S
Site-specific Smad3 linker region phosphorylation as a marker in cholangiocarcinoma
Woller, N
Engaging antiviral antibodies for tumor therapy using bispecific adapter proteins
Analysis of T cell exhaustion in tumor-specific CD8 T cells utilizing an orthotopic hepatocellular carcinoma mouse model
Genetically flexible murine organoids for mechanistic and functional modeling of cholangiocarcinoma
Wolters, F
Hepatozelluläre Aktivierung von β-Catenin und Survivin durch Schistosoma mansoni Infektion im Hamster-Modell
Wong, HY
Externalization of phosphatidylethanolamine in hepatocytes from male mice is increased by iPLA2β deficiency associated with cellular oxidative stress
Wormser, L
Expression and function of neuroblastoma RAS viral oncogene homolog (NRAS) in hepatocellular carcinoma
Wörns, M
Exploring molecular basis of therapy response in patient derived primary liver cancer cell lines
Wörns, MA
Steatosis and associated proteins in hepatocellular adenoma
Wöstemeier, A
Visualization and analysis of inflammatory type T-cells in autoimmune hepatitis
Wunderlich, T
A novel mouse model to study effects of cell-autonomous gp130 activation on infection, inflammation and tumour formation in the liver
Wupperfeld, D
Delivery of Copper-chelating Trientine (TETA) to the central nervous system
Xiao, Y
MiRNAs involved in development of intraepithelial precursor lesions and progression to cholangiocarcinoma
Xu, M
Loss of Axin1 induced hepatocarcinogenesis requires intact β-Catenin but not Notch cascade in mice
MEK inhibition suppresses cholangiocarcinoma growth by restraining tumor cell proliferation and modulating tumor microenvironment
Ye, L
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Yin, Y
CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
Yu, X
Metabolic Changes upon Inhibition of the Lysine-Specific-Demethylase-1 (LSD1) in Hepatocellular Carcinoma
Epigenitic Modifications by the Histone Demethylase LSD1 in Hepatic Stellate Cells Contribute to Liver Fibrosis
MiR-198 overexpression leads to its vesicular release from hepatocellular carcinoma cells
Yuan, X
Maintenance of functional hepatocellular polarity determines recovery in acute-on-chronic liver failure
Transcription factor TRIM33 controls liver progenitor cell towards hepatocyte differentiation through synergizing with phosphorylated Smad2/3 in liver cirrhosis
Yurdaydin, C
A rapid point-of-care device for the diagnosis of Hepatitis Delta Virus infection
Zamboni, N
The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
Zaza, A
A mouse model of chronic liver disease progression and acute-on-chronic liver failure
CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
Zehe, S
Inefficient induction of TAA-specific CD8+ T-cell responses in hepatocellular carcinoma
Zehnder, B
Hepatitis B virus (HBV) DNA integration is not driven by viral proteins
Zeissig, S
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
Loss of zonation in end stage liver disease revealed by in situ omics
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Hepatocyte-derived calcineurin regulates the development of hepatocellular carcinoma independent of hepatic steatohepatitis
Zender, L
Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Mutation of PRSS23 promotes HCC development via activation of AKT/PI3K/mTOR signaling
Zenouzi, R
Metamizole: an underrated agent causing drug-induced liver injury (DILI) in Germany
Altered microbiota and bile acid composition in patients with primary sclerosing cholangitis
Signifikante histologische Entzündungsaktivität trotz normwertiger Serum-ALT bei Patienten mit Autoimmuner Hepatitis und Leberzirrhose
Zenzusi, R
Monocytes as a potential trigger of Th17-differentiation in primary sclerosing cholangitis (PSC)
Zeuzem, S
Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
Impaired adaptive immunity is an early event in liver cirrhosis preceding acute-on-chronic liver failure
Baseline patient characteristics of the German multicentric prospective real-world NAFLD cohort: The Fatty Liver Assessment in Germany (FLAG) study
High real-world efficacy of elbasvir/grazoprevir (EBR/GZR) in genotype 1 (GT1) infected patients with and without liver cirrhosis: results from the German Hepatitis C Registry (DHC-R)
IL-22 and IL22-binding protein are associated with development of and mortality from acute-on-chronic liver failure (ACLF)
Zhan, T
Pharmacological treatment of hepatocellular cancer with cavoatrial tumor thrombus – case series and literature review
Zhang, X
Hepatocyte-specific deletion of Brg1 prevents CCl4-induced liver fibrosis in mice
Zhang, Z
IFN response suppresses HDV persistence during hepatocytes proliferation in vitro
Hepatitis B virus particles activate toll-like receptor 2 signaling initial upon infection of primary human hepatocytes
Zhang-Hagenlocher, C
The rs626283 Variant in the MBOAT7 Gene is Associated with reduced survival in primary biliary cholangitis
Obeticholic acid for the treatment of primary biliary cholangitis – first data from a real world cohort
Evaluation of serological markers of extracellular matrix remodeling in primary sclerosing cholangitis
Zhao, G
Combined function of c-Jun N-terminal kinases in hepatocytes protects mice from fibrosis development during cholestatic liver injury
Zhao, J
CYP2E1 recovery is associated with a pericentral fibrosis pattern after repeated CCl4 insults
Zheng, K
Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
Zhivkova, N
Sirtuin 6 regulates innate immune responses in a syngeneic mouse model of hepatocellular carcinoma
Zhu, X
iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet
iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes
Zhuang, Y
B cell-mediated maintenance of CD169+ cells is critical for liver regeneration
Ziesch, A
Akalzämische Vitamin-D-Analoga zeigen antifibrotische Effekte in vitro in hepatischen Sternzellen und in vivo im CCl4-Mausmodell
Zimmermann, A
Cytomegalovirus limits formation of intrahepatic myeloid-cell aggregates for T-cell population expansion by activating both MAPKAP kinases 2 and 3
Zimmermann, HW
Intestinal dysbiosis drives liver disease progression via NLRP3 in the Mdr2-/- model of primary sclerosing cholangitis
Zimmermann, M
Hepatic encephalopathy is linked to alterations of autophagic flux in astrocytes caused by hyperammonemia
Zimmermann, P
Phenotypic and functional differences of HBVcore- versus HBVpolymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Ziol, M
Serum CYFRA 21 – 1 levels are elevated in advanced liver disease and associate with poor survival
Zipprich, A
Protektiver Effekt von Statinen auf die Entstehung der heptischen Enzephalopathie ist abhängig von häufigen Genvarianten
Zizer, E
Der Einsatz einer permanenten Aszitesdrainage bei Patienten mit therapierefraktärem Aszites bei Peritonealkarzinose und end-stage-Leberzirrhose: Vergleich des Komplikationen- und Sicherheitsprofils
Evaluation des Stellenwertes der cfDNA-Serumkonzentration für portale Hypertension bei Leberzirrhose
Zoldan, K
Clearance of chronic HCV infection leads to an expansion of a follicular T helper cell memory phenotype in HCV-specific CD4 T cells
Combined OX40 stimulation and PD-L1 blockade reinforce HBV-specific CD4 T cell responses
Type I Interferons promote maintenance and function of follicular T helper cells in vitro
Zoller, H
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis
In severe alcoholic hepatitis, serum transferrin predicts mortality independently of disease severity
Quantification of hepatic liver iron overload with laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
Zopf, S
Carriage of HSD17B13 rs72613567TA is associated with a reduced risk for developing hepatocellular carcinoma in patients with alcohol-related cirrhosis
Zoubek, ME
Modulation of hepatocyte-specific c-Jun N-terminal kinase 2 (JNK2) during chronic liver disease using gene silencing
Zucman-Rossi, J
miR-193a-5 p regulates NUSAP1 expression to suppress hepatocarcinogenesis
Zweerink, S
The damage of tight junction proteins in elder MDR 2-/- knockout mice: A question of cholestasis?
Zwerina, J
Variants in TM6SF2, PNPLA3 and PCSK7 are risk factors for the development of cirrhosis in people with genetic haemochromatosis