DOI : 10.1055/s-00000094

Zeitschrift für Gastroenterologie

Issue 01 · Volume 57 · January 2019 DOI: 10.1055/s-008-42145

Deutsche Arbeitsgemeinschaft zum Studium der Leber (GASL)
35. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber
Heidelberg, 22.–23.02.2019

Kongresspräsident: Prof. Dr. Ralf Bartenschlager
Abstracts (HTML) List of Authors
P3.1
Aprupe, L; Liu, K; Schmitt, J; Weiler, SE; Ghallab, A; Hengstler, JG; Schirmacher, P; Kummer, U; Breuhahn, K: Acetaminophen (APAP)-induces a dynamic response of the Hippo pathway and its effector yes-associated protein (YAP) in hepatocellular cells
P3.2
Gaitantzi, H; Cai, C; Herrera Gonzalez, BM; Sànchez Munoz, A; Ebert, MP; Breitkopf-Heinlein, K: Characterization of the liver phenotype of the BMP-9 knock-out mouse
P3.3
Gan-Schreier, H; Tuma-Kellner, S; Chamulitrat, W: Liver specific-deletion of FATP4 increases hepatic triglycerides upon D8-glycerol administration: a stable isotope labelling study
P3.4
Guo, F; Zheng, K; Benedé-Ubieto, R; Estévez Vázquez, O; Ramadori, P; Woitok, MM; Chen, C; Trautwein, C; Liedtke, C; Cubero, FJ; Nevzorova, YA: c-MYC overexpression in hepatocytes is associated with spontaneous development of non-alcoholic steatohepatitis (NASH) in mice
P3.5
Irungbam, K; Churin, Y; Ocker, M; Roderfeld, M; Roeb, E: CB1 knockout alleviates hepatic steatosis via lipophagy and lipolysis in HBs transgenic mice
P3.6
Kleeschulte, S; Häussinger, D; Bode, JG: Deletion of thrombin receptor PAR4 attenuates the development of insulin resistance and NAFLD in mouse fed high-fat diet
P3.7
Kolbe, E; Meierhofer, D; Gajowski, R; Stöpel, C; Höhme, S; Hampe, J; Brosch, M; Hofmann, U; Oppermann, H; Gebhardt, R; Matz-Soja, M: Wnt/β-Catenin and Hh signaling in the adult liver – an insight into distribution, interaction and regulation
P3.8
Koop, A; Heeren, J; Lohse, AW; Kluwe, J: LPL-Defizienz in myeloiden Zellen verstärkt die Progression der nicht-alkoholischen Steatohepatitis
P3.9
Kotsiliti, E; Leone, V; Pfister, D; O'Connor, T; Li, H; Healy, M; Waisman, A; Haller, D; Heide, D; Macpherson, A; Knolle, PA; Weber, A; Heikenwälder, M: Involvement of B cells in Non-Alcoholic Steatohepatitis (NASH)
P3.10
Kremer, AE; Gebhardt, L; Robering, J; Kühn, H; Wolf, K; Fischer, MMJ: Lysophosphatidic acid activates peripheral glial cells
P3.11
Lederer, P; Roderfeld, M; Kroy, DC; Roeb, E; Geier, A; Hermanns, HM: Progression of fatty liver disease to steatohepatitis and liver fibrosis is associated with altered Oncostatin M type I and type II receptor expression
P3.12
Mahli, A; Koch, A; Lee, S; Thasler, WE; Bosserhoff, AK; Hellerbrand, C: Hepatic steatosis potentiates irinotecan-induced hepatocellular steatohepatitis via dysregulation of irinotecan-metabolizing enzymes
P3.13
Malehmir, M; Pfister, D; Gallage, S; Szydlowska, M; Inverso, D; Kotsiliti, E; Leone, V; Peiseler, M; Surewaard, BGJ; Rath, D; Prinz, M; Augustin, H; Llovet, JM; Pinyol, R; Tacke, F; Rad, R; Djouder, N; Kubes, P; Knolle, PA; Unger, K; Zender, L; Nieswandt, B; Gawaz, M; Weber, A; Heikenwälder, M: Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer
P3.14
Manka, P; Bechmann, L; Sydor, S; Best, J; Canbay, A; Gerken, G; Syn, WK; Wedemeyer, H: Low free triiodothyronine (fT3) is associated with advanced fibrosis in non-alcoholic steatohepatitis (NASH)
P3.15
Ming, Y; Zhu, X; Tuma-Kellner, S; Gan-Schreier, H; Chamulitrat, W: iPLA2b Deficiency Exacerbates an Increase of Bile Acids in the Enterohepatic Circulation by Downregulating Hepatic FXR in Mice fed with Methionine-choline-deficient Diet
P3.16
Nati, M; Chatzigeorgiou, A; Chen, LS; Neuwirth, A; Subramanian, P; Hampe, J; Soehnlein, O; Chavakis, T: The role of Formyl Peptide Receptor 1 in the development of non-alcoholic steatohepatitis
P3.17
Nwosu, ZC; Pioronska, W; Ebert, MP; Meyer, C; Dooley, S: Glutamine deprivation link impaired metabolism to ERK pathway activation and drug resistance in liver cancer
P3.18
Pleli, T; Finkelmeier, F; Ferreirós, N; Thomas, D; Schmithals, C; Rasech, S; Mondorf, A; Schaarschmidt, V; Harten, M von; Badenhoop, K; Zeuzem, S; Christen, U; Geisslinger, G; Moolenaar, W; Waidmann, O; Piiper, A: Hepatocellular autotaxin is a major source of systemic lysophosphatidic acid and regulates glucose homeostasis
P3.19
Ramadori, P; Hennings, J; Woitok, MM; Zheng, K; Cubero, FJ; Trautwein, C; Liedtke, C; Nevzorova, YA: Lack of Cyclin E1 aggravates ethanol-induced liver injury and hepatic steatosis in the murine model of acute ALD
P3.20
Rau, M; Krawczyk, M; Paukstat, K; Lammert, F; Geier, A: The NLRP3 inflammasome rs10754558 is associated with increased serum ALT activities: analysis of a prospective NAFLD cohort
P3.21
Reichel, F; Brosch, M; Kattler, K; Herrmann, A; Schönfels, W von; Nordström, K; Seehofer, D; Damm, G; Becker, T; Zeissig, S; Nehring, S; Moser, V; Thangapandi, RV; Stickel, F; Baretton, G; Röcken, C; Muders, M; Matz-Soja, M; Krawczak, M; Gasparoni, G; Hartmann, H; Dahl, A; Schafmayer, C; Walter, J; Hampe, J: Loss of zonation in end stage liver disease revealed by in situ omics
P3.22
Riepl, J; Schilcher, K; Vlaic, S; Guthke, R; Melter, M; Weiss, TS: Palmitic acid treatment alters expression of arachidonic-acid pathway associated genes in hepatoma cells linking fatty acids to inflammation
P3.23
Schilcher, K; Riepl, J; Melter, M; Weiss, TS: Gesättigte Fettsäure Palmitat induziert Amphiregulin durch Aktivierung von Stress induzierten Signalwegen wie PKC
P3.24
Seeßle, J; Gan-Schreier, H; Stremmel, W; Chamulitrat, W; Merle, U: Phospho- and sphingolipid metabolism is altered in hereditary hemochromatosis independent of iron content and PNPLA3 polymorphism
P3.25
Singh, I; Leone, V; Li, X; Pfister, D; Stadler, M; Kotsiliti, E; Rössler, S; Barreto, G; Alexandrov, T; Pikarsky, E; Weber, A; Heikenwälder, M: Dysregulated epigenetic factors in non-alcoholic fatty liver disease and triggered liver cancer
P3.26
Sommer, J; Freese, K; Lee, SML; Thasler, WE; Bosserhoff, AK; Hellerbrand, C: Chain length and saturation status of fatty acids significantly affect cellular injury and lipid metabolism of primary human hepatocytes
P3.27
Spormann, L; Ott, F; Lehmann, R; Gebhardt, R; Matz-Soja, M: The interactions of Hedgehog and mTor signaling in Hepatocytes
P3.28
Stadler, M; Rappez, L; Alexandrov, T; Heikenwälder, M: Identification of Molecular Mechanisms by which NASH-derived Inflammation alters Hepatic Lipid Metabolism
P3.29
Subramanian, P; Grzybek, M; Palladini, A; Sinha, A; Gargani, S; Mitroulis, I; Lesche, M; Burkhardt, R; Brosch, M; Techritz, N; Witt, A; Chung, KJ; Nati, M; Dahl, A; Mirtschink, P; Zamboni, N; Coskun, Ü; Hampe, J; Kontoyiannis, D; Chavakis, T: The RNA binding protein HuR is a master regulator of hepatic-lipid homeostasis
P3.30
Sydor, S; Wenning, C; Aßmuth, S; Messerschmidt, I; Best, J; Brodesser, S; Vilchez-Vargas, R; Gerken, G; Canbay, A; Bechmann, L: Auswirkung einer Binge Eating Episode auf Leberschädigung, den Gallensäuremetabolismus und Zelltodmarker
P3.31
Winkler, S; Kratochvil, I; Hempel, M; Kühne, H; Kalkhof, S; Baumann, S; Schubert, K; Bergen, M von; Christ, B: Metabolische Wirkungen mesenchymaler Stromalzellen in der nicht-alkoholischen Steatohepatitis
P3.32
Witzel, HR; Schwittai, I; Pawella, LM; Rausch, V; Mueller, S; Schattenberg, JM; Schirmacher, P; Roth, W; Straub, BK: Lipid droplet-associated proteins in alcoholic and non-alcoholic steatohepatitis in patients with polymorphisms in PNPLA3
P3.33
Zhu, X; Otto, AC; Gan-Schreier, H; Cheng, Y; Tuma-Kellner, S; Ganzha, A; Liebisch, G; Chamulitrat, W: iPLA2beta Deficiency in mice fed methionine-choline-deficient diet does not protect hepatic steatosis but still attenuates hepatic fatty acids, cholesterol esters, and liver enzymes