DOI: 10.1055/s-00000131

Synfacts

Issue 03 · Volume 16 · March 2020 DOI: 10.1055/s-010-45949

Synform

A31
SYNFORM ISSUE 2020/03

Synthesis of Natural Products and Potential Drugs

z0245
All PDFs of this category
0245
Total Synthesis of Swinhoeisterol A, Dankasterones A and B, and Periconiastone A
0246
Total Syntheses of (+)-Lyconadins D and E
0247
Synthesis of a Macrocyclic Mcl-1 Inhibitor
0248
Synthesis of d9-Ivacaftor Using o-Quinone Methide Chemistry
0249
Synthesis of Sonidegib Using Palladium Catalysis in Water
0250
Synthesis of (–)-Oridonin
0251
Synthesis of Taniborbactam
0252
Synthesis of β-Lactamase Inhibitor Relebactam
0253
Synthesis of (–)-Curvulamine
0254
Synthesis of a Baloxavir Marboxil Fragment
0255
Total Synthesis of (–)-PF-1018
0256
Synthesis of O-GlcNAcase Inhibitor MK-8719
0257
Synthesis of ERK1/2 Inhibitor AZD0364
0258
Synthesis of AMG 510
0259
Synthesis of Axelopran
0260
Synthesis of (+)-Tronocarpine
0261
Synthesis of (±)-Tetrodotoxin

Synthesis of Heterocycles

z0263
All PDFs of this category
0263
One-Step Synthesis of 4-Fluoropyrimidines
0264
Synthesis of Benzofuroindolines through Biocatalytic Oxidative Phenol–Indole [3+2] Reactions
0265
Palladium-Catalyzed Ring Expansion for the Synthesis of 12-Membered Heterocycles
0266
Synthesis of Butenolides from Functionalized Cyclopropenones
0267
Electrochemical Synthesis of trans-2,3-Disubstituted Aziridines
0268
Regioselective Synthesis of CF2H-Containing Pyrazoles
0269
Enantioenriched Dihydroquinolines by NHC Catalysis
0270
Diastereoselective Cyclization of Oxime-Tethered Cyclopropanes to Pyrrolooxazines
0271
Light-Mediated Dehydrogenative Povarov Reaction of Indoles and Benzofurans
0272
Stereoselective and Regioselective Functionalization of Piperidines through C–H Activation
0273
The N-Oxide Moiety as a Traceless Directing Group for Pyridine 2-C(O)–C Bond Activation
0274
Asymmetric Palladium-Catalyzed Synthesis of Fluoropiperidines
0275
Modified Pomeranz–Fritsch Reaction for the Synthesis of 1,2-Dihydroisoquinolines

Synthesis of Materials and Unnatural Products

z0277
All PDFs of this category
0277
Dendralenes and Radialenes and Butadienes, Oh My!
0278
Two ‘L’s are a Win for Fluorescent Helical Foldamers
0279
Close to N-Doped Zigzag Carbon Nanobelts
0280
A Palladium-Catalyzed Tandem Reaction to Construct bis-BN-Naphthalene-Fused Oxepins
0281
Synthesis of Fold-Line-Shaped BN-Embedded Polycyclic Aromatic Hydrocarbons
0282
Helical Nanographenes: Now with Azulene
0283
Stereospecific PAH Synthesis with a Twist
0284
Covalently Linked Dimers with Intramolecular Stacking
0285
Gold-Digging Polythioamides via Sulfur, Acid and Amine Polymerization
0286
Little PolyANIs
0287
Supramolecular Pi
0288
Oxygen/Sulfur Exchange in Epoxides to Make Poly(thioethers)

Metals in Synthesis

z0289
All PDFs of this category
0289
Palladium-Catalyzed Dicarbonylation of 1,3-Dienes for the Synthesis of Adipic Acid Esters
0290
Dual-Catalyzed 1,2-Difunctionalization of Vinyl Boronates
0291
Synthesis of C-Alkyl Glycoamino Acids via Palladium-Catalyzed C(sp3)–H Glycosylation
0292
Nickel-Catalyzed Hydroalkylation of Olefins
0293
Iron-Electrocatalyzed C–H Arylations
0294
Synthesis of Acylsilanes via Carbonylative Silylation of Alkyl Halides Using Copper Catalysis
0295
Reduction of Amides and Esters with Borane Dimethyl Sulfide Complex
0296
Hydroamination of Olefins
0297
Hydroamination of Cyclobutenes and Cyclopropenes
0298
Highly Selective Rhodium-Catalyzed Tandem Spirocyclization/Reduction of 3‑Allenylindoles
0299
Enantioselective Rhodium-Catalyzed C–H Borylation of N-Alkylamines and Amides
0300
Dual Photoredox/Nickel-Catalyzed Preparation of Aryl Aminooxetanes
0301
Nickel/Photoredox Dual Catalysis Mediated Dicarbofunctionalization of Olefines
0302
Iron-Catalyzed Allylic and Propargylic C–H Functionalization for the Formation of C–C Bonds
0303
Enantioselective C(sp3)–H Amidation under Rhodium Catalysis
0304
Conjunctive Cross-Coupling of Vinyl Boronic Esters
0305
[4+2] Cycloaddition of Dienes with Vinylcarbenes
0306
A New para-Selective Difluoroalkylation
0307
Regioselective Aziridine Opening
0308
Nickel-Catalyzed Synthesis of Homoallylic Alcohols under Photoredox Conditions
0309
Thiiranes and Thiethane Oxyalkynylation through a Copper-Catalyzed Ring Opening
0310
Enantioselective Pd-Catalyzed Desymmetrization of Cyclohexanones: γ‑All-Carbon Quaternary Centers
0311
Palladium-Catalyzed Dearomative [2+2+1] Spiroannulation through Alkyne-Directed C–H Activation
0312
Enantioselective Rhodium-Catalyzed Dearomatization of Pyridinium Salts
0313
Photoredox- and Cobalt-Catalyzed Intermolecular Reductive Ene-Yne Coupling
0314
The Stille Carbonylative Cross-Coupling Reaction
0315
Directed Metalation Using TMP2AgCNLi2
0316
Difluoromethylation of Benzylic C–H Bonds via Copper Catalysis

Polymer-Supported Synthesis

z0317
All PDFs of this category
0317
Shape-Selective Hydrogenation of Nitroarenes by Using Zeolite-Encaged Single-Atom Rhodium Catalysts
0318
Synthesis of Chromenopyrimidines on Cobalt Oxide–Nickel Oxide–Sulfonated Graphene Quantum Dots
0319
Oxygenation of Olefins with N-Doped Carbon-Incarcerated Cobalt Nanoparticles
0320
Dehydrogenation and Hydrogen-Borrowing Reactions with a P-Doped Polymer-Supported Iridium Catalyst
0321
Photodehydrogenation of N-Heterocycles on Nickel(II)-Grafted Titanium Dioxide
0322
Palladium Nanoparticle Catalyzed Suzuki–Miyaura Cross-Coupling under Ultrasonic Irradiation
0323
Micellar Cross-Coupling of Aryl Halides with N-Tosylhydrazones Catalyzed by Palladium Nanoparticles
0324
Synthesis of Chromeno[b]pyridines under Ultrasonic Irradiation using TiO2 NPs on Carbon Nanotubes
0325
Photoinduced Aerobic C–C Coupling of Xanthenes on Sulfated Carbon Dots
0326
Continuous-Flow Asymmetric Transfer Hydrogenation of Acetophenones with Propan-2-ol
0327
Silica-Supported Manganese(II) Catalyst for Carbonyl Hydrosilylation, Hydroboration, and Transesterification
0328
One-Pot Synthesis of Propargylamines on a Zinc Chloride Loaded Titania Catalyst
0329
Cycloaddition of Carbon Dioxide to Epoxides on a Hollow Zn–Co Based Zeolitic Imidazole Framework

Organo- and Biocatalysis

z0331
All PDFs of this category
0331
Foldamer-Catalyzed Macrocyclizations
0332
Lewis-Basic Peptide-Catalyzed Coupling of Naphthols and Quinones to Non-C2-Symmetric Biaryls
0333
Efficient Enzymatic Cascade for the Biosynthesis of Islatravir
0334
Decarboxylative C(sp3)–X (X = O, NBoc, S) Bond Formation through Photoredox Catalysis
0335
Methyl Triptycen-1-yl Sulfide Catalyzed Electrophilic Aromatic Halogenation with N-Halosuccinimides
0336
NHC Catalysis Enables a Practical and General Organocatalytic Approach to C1-Deuterated Aldehydes
0337
Asymmetric Counteranion-Directed Catalysis Meets Supramolecular Chemistry
0338
Chiral Acyl Azolium Permits Dynamic Kinetic Resolution of Hydroxyphthalides
0339
Biocatalytic Cascade Reduction of Cyclic Enimines
0340
Nitrenium Salts as Hydrogen-Transfer Catalysts

Chemistry in Medicine and Biology

z0341
All PDFs of this category
0341
A Repurposed Chemotherapy Drug as C1 Synthon
0342
Permeable and Fluorogenic Nanoscopy Probes
0343
A Highly Selective Inhibitor of TBK1/IKKε
0344
Cell-Type-Specific Voltage Imaging Using Covalently Tethered Fluorophores
0345
A Versatile Cellular Target Engagement Probe for MPC2
0346
Natural PDE4 Inhibitor Toddacoumalone
0347
Bioinspired Nucleobase Caging
0348
Investigating TRPA1 Modulation with Noncovalent Piperidine Carboxamide Based Binders
0349
Staudinger Reduction-Activated Lysine for the Control of Protein Subcellular Localization and SUMOylation
0350
Total Synthesis of a Gene

Peptide Chemistry

z0351
All PDFs of this category
0351
Cyclic Peptides Synthesis with the Assistance of a Removable Activating Group
0352
Synthesis of syn-α,β-Diamino Esters through an Asymmetric Mannich Reaction
0353
Chiral Ammonium Salt Phase-Transfer-Catalyzed Synthesis of Quaternary β2,2-Amino Acids
0354
Hydroperoxide-Mediated Decarboxylative Acylation of Amines with α-Keto Acids
0355
Metal-Free Photochemical Synthesis of α-Amino Acid Derivatives
0356
Synthesis of α-Amino Acid Derivatives from Amines
0357
Synthesis of C-Terminal Glycopeptides
0358
Heterogeneous Catalysis for Amide Bond Formation
0359
Photocatalytic Amide-Bond Formation
0360
Enantioselective Synthesis of α-Aryl-β-amino Acids from N-Boc Imines and Homophthalic Anhydrides
0361
Rhodium-Catalyzed Synthesis of α-Amino Acid Derivatives
0362
Synthesis of α-Amino Acids by One-Pot Oxidation and Transamination of 1,2-Diols
0363
Chlorofusin Cyclic Peptide Synthesis

Flow Chemistry

z0365
All PDFs of this category
0365
Heterogeneous Catalysis in Continuous Flow
0366
Organocatalyzed Rauhut–Currier and [3+2] Annulation Domino Reaction under Flow Conditions
0367
Functionalized Aryl Azides through Aryllithium Generation in Flow
0368
Continuous Palladium-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source

Addendum

0370
Enzyme-Catalyzed Site-Selective C–H Amidation