DOI: 10.1055/s-00000131

Synfacts

Issue 07 · Volume 16 · July 2020 DOI: 10.1055/s-010-48793

Synform

  • A92

    SYNFORM ISSUE 2020/07

    • Synthesis of Natural Products and Potential Drugs

  • z0749

    All PDFs of this category

  • 0749

    Synthesis of (–)-Scabrolide A

  • 0750

    Synthesis of Tafluprost

  • 0751

    Synthesis of GDC-0022

  • 0752

    Total Synthesis of (±)-Phyllantidine

  • 0753

    Total Synthesis of Lycojaponicumin A

  • 0754

    Synthesis of a Carfilzomib Fragment

  • 0755

    Synthesis of Esketamine

  • 0756

    Total Syntheses of Kopsane Alkaloids

  • 0757

    Synthesis of (–)-Minovincine and (–)-Aspidofractinine

  • 0758

    Synthesis of an Indoleamine-2,3-Dioxygenase-1 Inhibitor

  • 0759

    Synthesis of a Phosphodiesterase 1 Inhibitor

  • 0760

    Synthesis of AZD9742

  • 0761

    Synthesis of AZD7648

  • 0762

    Synthesis of (–)-Spirochensilide A

  • 0763

    Synthesis of (±)-Daphnilactone A

  • 0764

    Synthesis of Lanraplenib

  • 0765

    Synthesis of Remdesivir (GS-5734) — A Candidate for the Treatment of Ebola and COVID-19 Infections

    • Synthesis of Heterocycles

  • z0767

    All PDFs of this category

  • 0767

    Automated Approach to the Modular Synthesis of Drug-Like Molecules

  • 0768

    Transition-Metal-Free Synthesis of 3,4-Disubstituted 2-Piperidinones

  • 0769

    Synthesis of Oxazolidines, Pyrrolidines and Mannich Bases from Aliphatic Aldehydes

  • 0770

    A Scalable Route to N-Difluoromethylated Heterocycles

  • 0771

    Modular Rhodium-Catalyzed Synthesis of Quinolines from Anthranils and Acrylic Acids

  • 0772

    Reactions of Epoxides, Thiiranes, Aziridines and Azirines with Cyanoform

  • 0773

    Synthesis of Alkene Carbonates by Carbon Dioxide Fixation Using Perfluorinated Triol Catalysts

  • 0774

    Palladium-Catalyzed β-Cycloalkenylation of Saturated Cyclic Ketones

  • 0775

    Palladium-Catalyzed Enantioselective Synthesis of Isoxazolines

  • 0776

    Rhodium-Catalyzed Synthesis of Isoquinolines from Aryl Ketones and Alkynes

  • 0777

    Ruthenium-Catalyzed Diastereoselective Synthesis of Tetrasubstituted Pyrrolidines

  • 0778

    One-Pot Synthesis of 2-Trifluoromethyl-6-azaindoles

  • 0779

    Copper-Mediated Synthesis of N2-Aryl-1,2,3-Triazoles

  • 0780

    Mild Synthesis of 3H-Indoles and Benzazepinones from Nonactivated Anilines

  • 0781

    Asymmetric Synthesis of Cyclopropane-Fused Pyrrolidines

    • Synthesis of Materials and Unnatural Products

  • z0783

    All PDFs of this category

  • 0783

    How Germane: Polyfluorobiaryls via C–H Functionalization Cross-Coupling

  • 0784

    Aminohelicenes to Helical ortho-Diketones

  • 0785

    Double or Nothing

  • 0786

    A New Member in the Family of Pyrazinophane

  • 0787

    N-Doped Nanotube with Periodic Defects

  • 0788

    Golden Gateway to Au(I)–Aryls

  • 0789

    No Directing Group? No Problem!

  • 0790

    A One-Step, Three-Component Reaction to Synthesize Phenothiazines

  • 0791

    One, Two, Five, Six: Guanidino-Naphthalenes Get New Tricks

  • 0792

    Texas-Sized BODIPY Analogues

  • 0793

    Multiple Arylation of Cubanes

  • 0794

    Peri-Peri: Spicy Radical Double Annulations

    • Metals in Synthesis

  • z0795

    All PDFs of this category

  • 0795

    Dual-Catalyst Photoinduced Alkenylation of Alkanes and Aldehydes via C–H Activation

  • 0796

    Intramolecular Hydroacylation of Benzaldehyde Derivatives by Cobalt-Catalyzed C–C Bond Cleavage

  • 0797

    Nickel-Catalyzed Enantioconvergent Coupling of Racemic Partners

  • 0798

    Asymmetric Allylation of N-Methyl Anilines by Palladium/Photoredox Cooperative Catalysis

  • 0799

    Nickel-Catalyzed Electrochemical Synthesis of Diarylmethanes

  • 0800

    Stereoselective Preparation of Fluoroenynes

  • 0801

    Ruthenium-Catalyzed ortho-C–H Arylation

  • 0802

    Synthesis of Enantioenriched Secondary Alcohols by Enantioselective Ru-Catalyzed Coupling of Two Alcohols

  • 0803

    Bicyclo[1.1.1]pentanes as Electrophiles for Iron-Catalyzed Cross-Coupling

  • 0804

    Palladium-Catalyzed Oxidation of β-C–H Bonds of Primary Alkylamines

  • 0805

    Dual Photoredox Catalysis for the C–H Arylation/Decarboxylative Vinylation of Cyclic Oxalates

  • 0806

    Ruthenium-Catalyzed Synthesis of Vinylamides

  • 0807

    Rhodium-Catalyzed Hydroaminative Cyclizations

  • 0808

    Enantioselective Annulation of N-Methoxybenzamides with Quinones by Rhodium-Catalyzed C–H Activation

  • 0809

    New Ru(II)-NHC-Diamine Precatalysts for Asymmetric Hydrogenation

  • 0810

    Cobalt-Catalyzed Synthesis of Eight-Membered Rings

  • 0811

    Photocatalyzed Difunctionalization of Carbonyls

  • 0812

    Photoredox-Catalyzed Diastereoselective C–H Arylation/Epimerization of Piperidines

  • 0813

    Iron-Catalyzed Photoinduced C–H Bond Amination Using Organic Azides

  • 0814

    Dual Cobalt Ruthenium Photoredox-Catalyzed Oxidative Hydrofunctionalization

  • 0815

    Chemo- and Enantioselective Reduction of β-Keto-Enamides by Transfer Hydrogenation

  • 0816

    Electrosynthetic Reductive Pyridylation of Alkenes in an Undivided Cell

  • 0817

    Iridium-Catalyzed Ring-Expansion Proceeding via Hydrogen Borrowing

  • 0818

    Enantioselective Copper-Catalyzed Cycloaddition: Preparation of Pyrrole-Fused Bridged [2.2.1] Scaffolds

  • 0819

    Synthesis of Functionalized Enamides via Rhodium-Catalyzed Cleavage of Triazoles

  • 0820

    Enantioselective Synthesis of Tetrahydrobenzofurans by Gold/Cobalt Dual Catalysis

  • 0821

    Photoinduced Copper-Catalyzed Alkynylation of Redox-Active Esters

  • 0822

    Dual Light-Driven Palladium-Catalyzed Carbonylation

  • 0823

    Miyaura Borylation Reaction

    • Polymer-Supported Synthesis

  • z0825

    All PDFs of this category

  • 0825

    Hydroformylation of Styrene Derivatives Catalyzed by Rhodium Single-Atoms Supported on CeO2

  • 0826

    Allylation of Aldehydes and Ketones Catalyzed by Cu-Impregnated Mg–La Mixed Oxide

  • 0827

    Dehydrogenative Coupling of Amines on Cobalt Nanoparticles Coated with N-Doped Graphene

  • 0828

    Synthesis of 1,4-Benzodiazepine Derivatives in Water Using Ni NPs Supported on CoFe2O4@GO-Kryptofix 22

  • 0829

    Oxidation of Alkenes to Ketones and 1,2-Diketones Catalyzed by a Bifunctional Iron Nanocomposite

  • 0830

    Oxidation of Alcohols in Water on a Mesoporous Polypyrrole/Carbon-Supported Palladium Catalyst

  • 0831

    Brønsted Acid Catalyzed Aromatic C–H Insertion of α-Aryl Diazoacetates with H2SO4–SiO2

  • 0832

    Synthesis of Chromeno-pyrido[d]pyrimidines by Using a Fe3O4@ZnO Nanocomposite Supported on Polyaniline

  • 0833

    Chemoselective Hydrogenation of 4-Chloronitrobenzene on a Supported Platinum Catalyst

  • 0834

    A Polyethylene-Supported Imidazolium Salt for the Synthesis of Cyclic Carbonates from CO2

    • Organo- and Biocatalysis

  • z0835

    All PDFs of this category

  • 0835

    Enzymatic Depolymerization of Poly(ethylene terephthalate)

  • 0836

    NHC-Catalyzed Radical Relay δ‑Ketocarbonyl Synthesis

  • 0837

    Lewis Acid Catalyzed Hydridodeamination

  • 0838

    Catalytic Hydroetherification of Alkenes Mediated by Proton-Coupled Electron Transfer

  • 0839

    Biocatalytic Functionalization of Primary and Secondary α-Amino C–H Bonds

  • 0840

    Unprecedented Selectivities in the C7-Hydroxylation of Steroids Enabled by a P450-BM3 Mutant

  • 0841

    DFT-Assisted Substrate Optimization Permits Desymmetrization of 1,3-Diol Acetals

  • 0842

    New Chiral P2-Phosphazene Organosuperbases Combine High Basicity and Control of Stereoselectivity

  • 0843

    Sulfide-Catalyzed Synthesis of Allylic gem-Difluorides through a Meyer–Schuster-Like Rearrangement

  • 0844

    Brønsted Acid Catalyzed Pseudotransannular Desymmetrization Permits Access to Tropanols

  • 0845

    Enantioselective Protonation of Enol Intermediates Derived from Light-Mediated C–H Functionalization

    • Chemistry in Medicine and Biology

  • z0847

    All PDFs of this category

  • 0847

    Selectively Binding a Bromodomain

  • 0848

    Bicyclic Arginase Inhibitors to Enhance Cancer Immunotherapy

  • 0849

    Sterically Shielded Heptamethine Cyanine Dyes with Enhanced Photophysical Properties

  • 0850

    DNA-Compatible Cycloadditions for Rapid Library Synthesis

  • 0851

    Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol–Thiol Bioconjugations

  • 0852

    Optical Control of Gene Silencing by Azobenzene-Modified siRNA

  • 0853

    A Nucleolus-Targeted, Photocaged Pt(IV) Prodrug Overcomes Cancer Resistance

  • 0854

    Unraveling Masked GPX4 Inhibitors

  • 0855

    The First Selective Inhibitor of DCLK-1

  • 0856

    How to Overcome Vancomycin Resistance

  • 0857

    Total Synthesis of Galactosyl-Queuosine

  • 0858

    A Broadly Reactive Covalent Ligand for Glutamates and Aspartates

  • 0859

    Chemoselective Methionine Bioconjugation in the Synthesis of Antibody Drug Conjugates (ADCs)

  • 0860

    Potent TAS2R8 Antagonists as Bitterness Blockers

  • 0861

    Chemically Induced Dimerization

  • 0862

    A Photocrosslinkable Mycobacteria Glycolipid Probe

    • Peptide Chemistry

  • z0863

    All PDFs of this category

  • 0863

    Synthesis of Peptides with Acyl N-Methylimidazolium Cations

  • 0864

    Photocatalytic Conjugate Addition of Amino Acids or Peptides

  • 0865

    Chiral Nonnatural α-Amino Acid Synthesis by Enantio-selective Mannich Reaction and Hydrogenation

  • 0866

    Base-Controlled Synthesis of α- and β-Amino Acid Derivatives from Azirine Rings and Arylacetic Acids

  • 0867

    Synthesis of Amino Acid Derivatives from Glycine Derivatives and Ketones/Aldehydes

  • 0868

    Conjugation of Two Peptides via Disulfide Linkage

  • 0869

    Iridium-Catalyzed Site-Selective Thiolation

  • 0870

    Iridium-Photocatalyzed Synthesis of Nonnatural α-Amino Acids

  • 0871

    Palladium-Catalyzed Synthesis of Glycopeptides through C–H Activation

  • 0872

    Amidation of Amino Acids with 4-[(Fluorosulfonyl)oxy]-benzoic Acid Toward Prodrugs

    • Flow Chemistry

  • z0873

    All PDFs of this category

  • 0873

    Synthesis of α-Chloro Aldehydes in a Flow Microreactor

  • 0874

    Generation and Use of Fluoroorganolithiums in Flow Microreactors