DOI: 10.1055/s-00000131

Synfacts

Issue 07 · Volume 16 · July 2020 DOI: 10.1055/s-010-48793

Synform

A92
Zanda, Matteo: SYNFORM ISSUE 2020/07

Synthesis of Natural Products and Potential Drugs

z0749
All PDFs of this category
0749
Synthesis of (–)-Scabrolide A
0750
Synthesis of Tafluprost
0751
Synthesis of GDC-0022
0752
Total Synthesis of (±)-Phyllantidine
0753
Total Synthesis of Lycojaponicumin A
0754
Synthesis of a Carfilzomib Fragment
0755
Synthesis of Esketamine
0756
Total Syntheses of Kopsane Alkaloids
0757
Synthesis of (–)-Minovincine and (–)-Aspidofractinine
0758
Synthesis of an Indoleamine-2,3-Dioxygenase-1 Inhibitor
0759
Synthesis of a Phosphodiesterase 1 Inhibitor
0760
Synthesis of AZD9742
0761
Synthesis of AZD7648
0762
Synthesis of (–)-Spirochensilide A
0763
Synthesis of (±)-Daphnilactone A
0764
Synthesis of Lanraplenib
0765
Synthesis of Remdesivir (GS-5734) — A Candidate for the Treatment of Ebola and COVID-19 Infections

Synthesis of Heterocycles

z0767
All PDFs of this category
0767
Automated Approach to the Modular Synthesis of Drug-Like Molecules
0768
Transition-Metal-Free Synthesis of 3,4-Disubstituted 2-Piperidinones
0769
Synthesis of Oxazolidines, Pyrrolidines and Mannich Bases from Aliphatic Aldehydes
0770
A Scalable Route to N-Difluoromethylated Heterocycles
0771
Modular Rhodium-Catalyzed Synthesis of Quinolines from Anthranils and Acrylic Acids
0772
Reactions of Epoxides, Thiiranes, Aziridines and Azirines with Cyanoform
0773
Synthesis of Alkene Carbonates by Carbon Dioxide Fixation Using Perfluorinated Triol Catalysts
0774
Palladium-Catalyzed β-Cycloalkenylation of Saturated Cyclic Ketones
0775
Palladium-Catalyzed Enantioselective Synthesis of Isoxazolines
0776
Rhodium-Catalyzed Synthesis of Isoquinolines from Aryl Ketones and Alkynes
0777
Ruthenium-Catalyzed Diastereoselective Synthesis of Tetrasubstituted Pyrrolidines
0778
One-Pot Synthesis of 2-Trifluoromethyl-6-azaindoles
0779
Copper-Mediated Synthesis of N2-Aryl-1,2,3-Triazoles
0780
Mild Synthesis of 3H-Indoles and Benzazepinones from Nonactivated Anilines
0781
Asymmetric Synthesis of Cyclopropane-Fused Pyrrolidines

Synthesis of Materials and Unnatural Products

z0783
All PDFs of this category
0783
How Germane: Polyfluorobiaryls via C–H Functionalization Cross-Coupling
0784
Aminohelicenes to Helical ortho-Diketones
0785
Double or Nothing
0786
A New Member in the Family of Pyrazinophane
0787
N-Doped Nanotube with Periodic Defects
0788
Golden Gateway to Au(I)–Aryls
0789
No Directing Group? No Problem!
0790
A One-Step, Three-Component Reaction to Synthesize Phenothiazines
0791
One, Two, Five, Six: Guanidino-Naphthalenes Get New Tricks
0792
Texas-Sized BODIPY Analogues
0793
Multiple Arylation of Cubanes
0794
Peri-Peri: Spicy Radical Double Annulations

Metals in Synthesis

z0795
All PDFs of this category
0795
Dual-Catalyst Photoinduced Alkenylation of Alkanes and Aldehydes via C–H Activation
0796
Intramolecular Hydroacylation of Benzaldehyde Derivatives by Cobalt-Catalyzed C–C Bond Cleavage
0797
Nickel-Catalyzed Enantioconvergent Coupling of Racemic Partners
0798
Asymmetric Allylation of N-Methyl Anilines by Palladium/Photoredox Cooperative Catalysis
0799
Nickel-Catalyzed Electrochemical Synthesis of Diarylmethanes
0800
Stereoselective Preparation of Fluoroenynes
0801
Ruthenium-Catalyzed ortho-C–H Arylation
0802
Synthesis of Enantioenriched Secondary Alcohols by Enantioselective Ru-Catalyzed Coupling of Two Alcohols
0803
Bicyclo[1.1.1]pentanes as Electrophiles for Iron-Catalyzed Cross-Coupling
0804
Palladium-Catalyzed Oxidation of β-C–H Bonds of Primary Alkylamines
0805
Dual Photoredox Catalysis for the C–H Arylation/Decarboxylative Vinylation of Cyclic Oxalates
0806
Ruthenium-Catalyzed Synthesis of Vinylamides
0807
Rhodium-Catalyzed Hydroaminative Cyclizations
0808
Enantioselective Annulation of N-Methoxybenzamides with Quinones by Rhodium-Catalyzed C–H Activation
0809
New Ru(II)-NHC-Diamine Precatalysts for Asymmetric Hydrogenation
0810
Cobalt-Catalyzed Synthesis of Eight-Membered Rings
0811
Photocatalyzed Difunctionalization of Carbonyls
0812
Photoredox-Catalyzed Diastereoselective C–H Arylation/Epimerization of Piperidines
0813
Iron-Catalyzed Photoinduced C–H Bond Amination Using Organic Azides
0814
Dual Cobalt Ruthenium Photoredox-Catalyzed Oxidative Hydrofunctionalization
0815
Chemo- and Enantioselective Reduction of β-Keto-Enamides by Transfer Hydrogenation
0816
Electrosynthetic Reductive Pyridylation of Alkenes in an Undivided Cell
0817
Iridium-Catalyzed Ring-Expansion Proceeding via Hydrogen Borrowing
0818
Enantioselective Copper-Catalyzed Cycloaddition: Preparation of Pyrrole-Fused Bridged [2.2.1] Scaffolds
0819
Synthesis of Functionalized Enamides via Rhodium-Catalyzed Cleavage of Triazoles
0820
Enantioselective Synthesis of Tetrahydrobenzofurans by Gold/Cobalt Dual Catalysis
0821
Photoinduced Copper-Catalyzed Alkynylation of Redox-Active Esters
0822
Dual Light-Driven Palladium-Catalyzed Carbonylation
0823
Miyaura Borylation Reaction

Polymer-Supported Synthesis

z0825
All PDFs of this category
0825
Hydroformylation of Styrene Derivatives Catalyzed by Rhodium Single-Atoms Supported on CeO2
0826
Allylation of Aldehydes and Ketones Catalyzed by Cu-Impregnated Mg–La Mixed Oxide
0827
Dehydrogenative Coupling of Amines on Cobalt Nanoparticles Coated with N-Doped Graphene
0828
Synthesis of 1,4-Benzodiazepine Derivatives in Water Using Ni NPs Supported on CoFe2O4@GO-Kryptofix 22
0829
Oxidation of Alkenes to Ketones and 1,2-Diketones Catalyzed by a Bifunctional Iron Nanocomposite
0830
Oxidation of Alcohols in Water on a Mesoporous Polypyrrole/Carbon-Supported Palladium Catalyst
0831
Brønsted Acid Catalyzed Aromatic C–H Insertion of α-Aryl Diazoacetates with H2SO4–SiO2
0832
Synthesis of Chromeno-pyrido[d]pyrimidines by Using a Fe3O4@ZnO Nanocomposite Supported on Polyaniline
0833
Chemoselective Hydrogenation of 4-Chloronitrobenzene on a Supported Platinum Catalyst
0834
A Polyethylene-Supported Imidazolium Salt for the Synthesis of Cyclic Carbonates from CO2

Organo- and Biocatalysis

z0835
All PDFs of this category
0835
Enzymatic Depolymerization of Poly(ethylene terephthalate)
0836
NHC-Catalyzed Radical Relay δ‑Ketocarbonyl Synthesis
0837
Lewis Acid Catalyzed Hydridodeamination
0838
Catalytic Hydroetherification of Alkenes Mediated by Proton-Coupled Electron Transfer
0839
Biocatalytic Functionalization of Primary and Secondary α-Amino C–H Bonds
0840
Unprecedented Selectivities in the C7-Hydroxylation of Steroids Enabled by a P450-BM3 Mutant
0841
DFT-Assisted Substrate Optimization Permits Desymmetrization of 1,3-Diol Acetals
0842
New Chiral P2-Phosphazene Organosuperbases Combine High Basicity and Control of Stereoselectivity
0843
Sulfide-Catalyzed Synthesis of Allylic gem-Difluorides through a Meyer–Schuster-Like Rearrangement
0844
Brønsted Acid Catalyzed Pseudotransannular Desymmetrization Permits Access to Tropanols
0845
Enantioselective Protonation of Enol Intermediates Derived from Light-Mediated C–H Functionalization

Chemistry in Medicine and Biology

z0847
All PDFs of this category
0847
Selectively Binding a Bromodomain
0848
Bicyclic Arginase Inhibitors to Enhance Cancer Immunotherapy
0849
Sterically Shielded Heptamethine Cyanine Dyes with Enhanced Photophysical Properties
0850
DNA-Compatible Cycloadditions for Rapid Library Synthesis
0851
Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol–Thiol Bioconjugations
0852
Optical Control of Gene Silencing by Azobenzene-Modified siRNA
0853
A Nucleolus-Targeted, Photocaged Pt(IV) Prodrug Overcomes Cancer Resistance
0854
Unraveling Masked GPX4 Inhibitors
0855
The First Selective Inhibitor of DCLK-1
0856
How to Overcome Vancomycin Resistance
0857
Total Synthesis of Galactosyl-Queuosine
0858
A Broadly Reactive Covalent Ligand for Glutamates and Aspartates
0859
Chemoselective Methionine Bioconjugation in the Synthesis of Antibody Drug Conjugates (ADCs)
0860
Potent TAS2R8 Antagonists as Bitterness Blockers
0861
Chemically Induced Dimerization
0862
A Photocrosslinkable Mycobacteria Glycolipid Probe

Peptide Chemistry

z0863
All PDFs of this category
0863
Synthesis of Peptides with Acyl N-Methylimidazolium Cations
0864
Photocatalytic Conjugate Addition of Amino Acids or Peptides
0865
Chiral Nonnatural α-Amino Acid Synthesis by Enantio-selective Mannich Reaction and Hydrogenation
0866
Base-Controlled Synthesis of α- and β-Amino Acid Derivatives from Azirine Rings and Arylacetic Acids
0867
Synthesis of Amino Acid Derivatives from Glycine Derivatives and Ketones/Aldehydes
0868
Conjugation of Two Peptides via Disulfide Linkage
0869
Iridium-Catalyzed Site-Selective Thiolation
0870
Iridium-Photocatalyzed Synthesis of Nonnatural α-Amino Acids
0871
Palladium-Catalyzed Synthesis of Glycopeptides through C–H Activation
0872
Amidation of Amino Acids with 4-[(Fluorosulfonyl)oxy]-benzoic Acid Toward Prodrugs

Flow Chemistry

z0873
All PDFs of this category
0873
Synthesis of α-Chloro Aldehydes in a Flow Microreactor
0874
Generation and Use of Fluoroorganolithiums in Flow Microreactors