DOI: 10.1055/s-00000131

Synfacts

Issue 06 · Volume 18 · June 2022 DOI: 10.1055/s-012-53544

Synform

  • A81

    SYNFORM ISSUE 2022/06

    • Synthesis of Natural Products and Potential Drugs

  • z0579

    All PDFs of this category

  • 0579

    Synthesis of Belzutifan

  • 0580

    Synthesis of Antimalarial INE963

  • 0581

    Total Synthesis of (–)-Grayanotoxin III

  • 0582

    Synthesis of (–)-Gukulenin B

  • 0583

    Synthesis of (–)-3-Oxoisotaxodione

  • 0584

    Asymmetric Synthesis of the Cyclohexyl Fragment of BMS-986251

  • 0585

    Synthesis of the Tricyclic Core of BMS-986251

  • 0586

    Total Synthesis of (–)-Daphenylline

  • 0587

    Synthesis of (–)-γ-Lycorane

  • 0588

    Large-Scale Synthesis of AZD4573

  • 0589

    Synthesis of KRASG12C Inhibitors

  • 0590

    Asymmetric Synthesis of Giredestrant

  • 0591

    Synthesis of (±)-Myrioneurinol

  • 0592

    Second-Generation Synthesis of BMS-986224

  • 0593

    Synthesis of Orexin 2 Receptor Agonist TAK-925

  • 0594

    Synthesis of MK-1029

  • 0595

    Process for the Manufacture of Giredestrant (GDC-9545)

  • 0596

    Synthesis of a KRASG12C Inhibitor

  • 0597

    Total Synthesis of (±)-Ishwarane

    • Synthesis of Heterocycles

  • z0599

    All PDFs of this category

  • 0599

    Cross-Coupling Approach to Partially Saturated Heterocycles

  • 0600

    Non-Radical-Mediated C–H Alkylation of Pyridines

  • 0601

    Regioselective Functionalization of Azoles

  • 0602

    C2-Selective SNH Amination of Pyrimidines through Selective Iminium Formation

  • 0603

    Robust Difluoromethylation of Nonactivated Ketones

  • 0604

    Synthesis of 5-Fluoroindolizines by Photocatalytic Defluorinative Coupling and SNV Cyclization

  • 0605

    2-Amino-3,3-difluoro-2,3-dihydrofurans from Difluorocarbenes and Enaminones

  • 0606

    Nickel-Mediated Allylation of Heterocycles

  • 0607

    Oxindole Synthesis through a Polar–Radical Crossover

  • 0608

    Naphthyridinone Formation through Palladium-Catalyzed Annulation of 1,6-Enynes and 2-Iodoanilines

  • 0609

    Synthesis of 2-Pyridones by Ring Expansion of Furans or γ-Lactams

  • 0610

    Gold and N-Heterocyclic Carbene Relay Catalyzed Synthesis of Pyrrole-Fused Lactones

  • 0611

    Selective Synthesis of Pyridines and Pyrimidines Using Isopropene Derivatives

  • 0612

    Synthesis of β-Aryl-γ-lactams and 2-Oxo-1,2-dihydroquinolines

    • Synthesis of Materials and Unnatural Products

  • z0613

    All PDFs of this category

  • 0613

    Trouncing the Troublesome Trilactam

  • 0614

    Nonperipheral Functionalization of Triazatruxenes

  • 0615

    Nucleophilic Cyclodehydration of Enantiomerically Pure Helical Quinones

  • 0616

    Bundling Fluorine and Iodine on Unactivated Alkenes

  • 0617

    Ring, Ring! Directed Aromatic Homologation

  • 0618

    Copper-Catalyzed Unsymmetrical Trimerization of Indole towards Isotriazatruxene

  • 0619

    An Iterative Synthetic Route towards Unsaturated and Partially Saturated [7]Helicenes

  • 0620

    Cycloaddition with Stannoles to Make PAHs

  • 0621

    Helicenes Featuring Azulene

  • 0622

    Annulation à la Alumina

  • 0623

    Belt-Like Expanded Carbaporphyrins

  • 0624

    Solution-Mediated Synthesis of Cove-Edged Nanographene

    • Metals in Synthesis

  • z0625

    All PDFs of this category

  • 0625

    Zirconium-Catalyzed Asymmetric β-Oxygen Elimination for the Desymmetrization of meso-Ketene Acetals

  • 0626

    Nickel-Catalyzed, Three-Component Silylalkylation and -Benzylation of Alkenes using Silylzinc Pivalates

  • 0627

    Biocatalytic Enantioselective 1-Carbon Ring Expansion via 1,2-Stevens Rearrangement

  • 0628

    Copper-Catalyzed Asymmetric Dynamic Kinetic C–P Coupling

  • 0629

    Cobalt-Catalyzed Aryl Cyanation of Symmetric Alkynes to Access E- and Z-Acrylonitriles

  • 0630

    Ni-Catalyzed Cyanation of Aryl Halides Using 1,4-Dicyanobenzene as an Easily Accessible Cyanide Source

  • 0631

    Pd-Catalyzed Deoxygenative Allylation and Olefination of Carbohydrates by an Umpolung Strategy

  • 0632

    NHCs as Remote Controls: Access to Isoindolines and β-Lactams via Pd-Catalyzed Remote C–H Functionalization

  • 0633

    Rhodium-Catalyzed Synthesis of Indanones via Ring Expansion of Benzocyclobutenones

  • 0634

    Dual NHC/Photocatalytic Dearomative Acyl Fluorination Reaction of Benzofurans

  • 0635

    Pd-Catalyzed Cross-Electrophile Coupling of Benzyl- and (Hetero)Arylbromides without External Reductant

  • 0636

    Selective Pd-Catalyzed β- and γ-C(sp3)–H Arylation of Aldehydes Enabled by Transient Directing Groups

  • 0637

    Cobalt- and Iridium-Catalyzed Mizoroki–Heck Reaction of Imidates Enabled by Energy and Electron Transfer

  • 0638

    Palladium-Catalyzed Synthesis of Chiral gem-Difluoromethylene-Containing 1,3-Dioxanes

  • 0639

    Rhodium-Catalyzed Transfer C−H Borylation of Alkenes with Vinyl Boronic Esters

  • 0640

    The A-Team: Iridium-Catalyzed Asymmetric Allylic Alkylation of Azaarenes (AAAA)

  • 0641

    Enantioselective Intramolecular Ir-Catalyzed Allylic Substitution Generating 8–11-Membered Lactones

  • 0642

    One-Carbon Homologation of Aryl Ketones via Formal 1,1-Insertion of Olefins via Rh-Catalyzed ‘Cut and Sew’

  • 0643

    Accessing Diamines from Free Amines via Nickel-Catalyzed Olefin Difunctionalization

  • 0644

    Deaminative Allylation of Katritzky Pyridinium Salts by Dual Cobalt/Organophotoredox Catalysis

  • 0645

    Triple Catalysis Enables the Preparation of Aromatic Aldehydes by a Desaturative Strategy

  • 0646

    Access to Chiral N-Alkylanilines by Enantioconvergent Alkylation with Racemic Tertiary Alkyl Electrophiles

  • 0647

    Desymmetrization of Malononitriles by Intramolecular Nickel-Catalyzed Reductive Cross-Coupling

  • 0648

    Ligand-Controlled Regiodivergent Asymmetric Cu-Catalyzed Carbonyl Addition of Vinyl Heteroarenes

  • 0649

    The Perfect Couple: Dehydrogenative Ring-Opening of Cycloalkanols by Cobalt/Organophotoredox Catalysis

  • 0650

    Catalyst-Controlled Regiodivergent Transformations of Internal Propargyl Esters

  • 0651

    The Narasaka–Heck Cyclization

    • Polymer-Supported Synthesis

  • z0653

    All PDFs of this category

  • 0653

    Acceptorless Alcohol Dehydrogenation with an Iron–Cobalt Double-Atom Catalyst

  • 0654

    Photocatalytic Synthesis of Trisubstituted Pyridines with Vinylene-Linked Covalent Organic Frameworks

  • 0655

    Borrowing-Hydrogen Reaction Catalyzed by Iridium on a Porous Polypyridine-Oxadiazole

  • 0656

    Palladium-Catalyzed Benzylic Oxidation of Alkylarenes with Water as an Oxygen Source

  • 0657

    Meerwein–Ponndorf–Verley Reduction on Zirconium(IV) Coordinated to Amberlyst-15

  • 0658

    Photocatalytic Giese-Type Reaction on a Truxene-Based Hypercrosslinked Polymer

  • 0659

    Intermolecular [2+2] Photocycloadditions of Aromatic Alkenes Promoted by CdSe Quantum Dots

  • 0660

    PdAu/g-C3N4-Catalyzed Hydrodeoxygenation of Benzaldehydes with Formic Acid as a Hydrogen Donor

  • 0661

    Three-Component Regioselective Cycloaddition by a Copper Single-Atom Catalyst Supported on C3N4

  • 0662

    Hydrophosphinylation of Alkenes Catalyzed by Single-Atom Copper on Aluminum-Doped Magnesia

  • 0663

    Carboxylation of Sodium Arylsulfinates with CO2 on a Potassium–Copper–Titania Composite

    • Organo- and Biocatalysis

  • z0665

    All PDFs of this category

  • 0665

    Modified Flavins Permit Catalytic Reductive Cyclization

  • 0666

    Organocatalytic Enantioselective Cascade Process for Constructing Azabicyclo[3.3.1]nonane Scaffolds

  • 0667

    Atroposelective Synthesis of N-Arylindoles by Brønsted Acid-Catalyzed Cyclization of Ynamides

  • 0668

    An Organocatalytic Approach for Remote C(sp3)−H Bond Hydroxylation

  • 0669

    Biocatalytic Synthesis of Azetidines by Enantioselective [1,2]-Stevens Rearrangement of Aziridines

  • 0670

    Biocatalytic Decarboxylative Bromination of Electron-Rich Cinnamic Acids

  • 0671

    Hypoiodite Permits Enantioselective Dearomatization of Indoles

  • 0672

    Biaryl Bond Formation Enabled by Biocatalytic Oxidative Cross-Coupling Reactions

  • 0673

    Photoredox Organocatalytic Enantioselective Synthesis of 1,7-Dicarbonyl Compounds via γ-Keto Radicals

  • 0674

    Dual Carbene and Photoredox Catalysis Permits Tandem Cyclization to Cyclic Benzylic Ketones

  • 0675

    Organocatalytic Hydrogen Atom Transfer System for C−H Functionalization

  • 0676

    Friedel–Crafts Polymerization Approach to Easily Recyclable Heterogeneous Chiral Phosphoric Acids

    • Chemistry in Medicine and Biology

  • z0677

    All PDFs of this category

  • 0677

    Targeted Protein Stabilization with DUBTACs

  • 0678

    Take it Easy on the Synthesis of Cannabidiol Derivatives

  • 0679

    Spatiotemporal Labeling Through Photocatalytic Oxidation of Dihydrotetrazines

  • 0680

    Acyl Silanes: The Newest Photoaffinity Labeling Probe

  • 0681

    LZ-2112 – A Diterpene that Potentiates Antibiotics

  • 0682

    A Dual Inhibitor as a Potential Treatment for Alzheimer’s Disease

  • 0683

    Scalable Synthesis of a Payload for Antibody–Drug Conjugate Studies

  • 0684

    Sweet Mannose Antibiotic: Stereoselective Synthesis and Stereochemical Assignment of A-94964

  • 0685

    Potent Anti-Gastric Cancer Alkaloids from Traditional Medicine

  • 0686

    Live-Cell Imaging of Glycosidase Activity Using Bis-Acetal-Based Fluorogenic Probes

  • 0687

    Enlightening a Radical: A Convergent Total Synthesis of (+)-Actinobolin and Potent Analogues

  • 0688

    Synthesis of the Potent Antibiotic Amycolamicin

  • 0689

    First Asymmetric Synthesis of (+)-Thienamycin

  • 0690

    Evaluation of Benzopyrrolizidinone Pharmacophores Against NMDA-Induced Nerve Cell Injury

    • Peptide Chemistry

  • z0691

    All PDFs of this category

  • 0691

    Dipeptide Synthesis by Two-Component Organocatalysis

  • 0692

    Site-Selective Alkylation for the Synthesis of Azapeptides

  • 0693

    Urethane-Protected Amino Acid N-Carboxyanhydride Synthesis in a Microflow System

  • 0694

    Nickel-Catalyzed Enantioselective Synthesis of Unnatural Amino Acids

  • 0695

    C–H Azidation of Peptides and Applications of the Products

  • 0696

    Arene Triazene Reaction for Macrocyclization of Unprotected Peptides

  • 0697

    Ruthenium-Catalyzed Synthesis of Unnatural Amino Acids through Transfer Hydrogenation of Enamides

  • 0698

    Iridium-Catalyzed N-Alkylation of α-Amino Esters and Amides

  • 0699

    Synthesis of Versatile N-Protected Amino Acid Esters from Aryl 4-Nitrosulfonates

  • 0700

    Construction of N,O-Acetals of Unnatural Amino Acids from Diethyl Mesoxalate Derivatives

    • Flow Chemistry

  • z0701

    All PDFs of this category

  • 0701

    Synthesis of (R)-Tamsulosin Using Heterogeneous Catalysis in Flow

  • 0702

    Amide Bond Formation under Flow Conditions