DOI: 10.1055/s-00000131

Synfacts

Issue 11 · Volume 18 · November 2022 DOI: 10.1055/s-012-55462

Synform

A167
SYNFORM ISSUE 2022/11

Synthesis of Natural Products

z1167
All PDFs of this category
1167
Synthesis of (–)-10-Deoxydaphnipaxianine A, (+)-Daphlongamine E and (+)-Calyciphylline R
1168
Total Synthesis of Indole Alkaloid (+)-Alstonlarsine A
1169
Total Synthesis of the Grayanoid (+)-Mollanol A
1170
Synthesis of (+)-Mutilin
1171
Total Syntheses of (–)-Napelline
1172
Total Synthesis of (+)-Aberrarone
1173
Total Synthesis of (–)-Ircinol A, (+)-Ircinal A

Synthesis of Heterocycles

z1175
All PDFs of this category
1175
Selective N2-Alkylation of 1H-Azaindazoles
1176
Synthesis of 6-Phenanthridines by Photocatalytic Deoxygenation of Alcohols
1177
Synthesis of Versatile Enantiopure Morpholine Fragments from Chiral-Pool Starting Materials
1178
Multicomponent-Reaction-Triggered Cascade Approach to Functionalized Fused 2,6-Diketopiperazines
1179
Design and Synthesis of Azaborine-Based Steroid Mimics
1180
Silver-Catalyzed Synthesis of Densely Functionalized gem-Difluorinated Molecules
1181
Mechanistic Insights into Light-Mediated C–H Functionalization of 2-Phenylpyridines
1182
Furans by Rhodium-Catalyzed Tandem Cyclization of Acrylic Acids
1183
Microwave-Assisted Synthesis of Tertiary Amines from Carbamates
1184
Synthesis of Spiro[furan-2,1′-isoindolin]-3′-ones by Intramolecular Sequential Prins and Ritter Reactions
1185
Nickel-Mediated C(sp2)–C(sp3) Cross-Couplings

Synthesis of Materials and Unnatural Products

z1187
All PDFs of this category
1187
Transition-Metal Catalyzed Chain-Growth Conjugated Polymers
1188
Bisurea-Functionalized Tetraazaperylene
1189
Traceless Template for All-benzene Catenane
1190
Expanded Radialenes and Their Aromatic Dianions
1191
Silver and Gold Go Hand in Hand
1192
Metathesis of Electron-Deficient Alkenes
1193
Biomimetic Synthesis of Benzothiophene Sulfoxides
1194
Acenes Fused with Azulene
1195
Highly Strained Naphthalenonaphthalenophane
1196
Ring-Fused Hexameric Perylene Diimide
1197
Ester Exchange as Pivot to Block Polyolefins
1198
A Triplet Ground State Kekulé Hydrocarbon

Metals in Synthesis

z1199
All PDFs of this category
1199
Palladium-Catalyzed Butafulvene Synthesis
1200
Iridium-Catalyzed Enantioselective and Diastereodivergent Propargylic C(sp3)–H Allylation
1201
1,1-Difunctionalization of Terminal Alkenes to Chiral Allylboronates under Nickel Catalysis
1202
Enantioselective Synthesis of gem-Diarylmethylsilanes via a Three-Component Coupling Reaction
1203
Accessing Cyclopropenium Cations via a Rh-Catalyzed Oxidative [2+1] Reaction
1204
Copper-Catalyzed Vinylogous and Bisvinylogous Asymmetric Propargylic Substitution
1205
Stereodivergent Cross-Coupling of Aryl Halides with Redox-Active Imines
1206
Enantioconvergent Benzylic C–H Azidation of Indolines Enabled by a Cationic Manganese Salen Catalyst
1207
Palladium-Catalyzed Diolefination/Cyclization Reaction of o-Toluidine with Acrylates
1208
Synthesis of Isocytosine Analogues via Palladium-Catalyzed Ring-Opening/Arylation/Cyclization Cascade
1209
Copper(I)-Catalyzed Kinugasa/C–C Coupling Domino Reaction Towards Spirocyclic Oxindoles
1210
Turning Aliphatic Carboxylic Acids into Fluorides under Iron Catalysis and Visible Light
1211
Pd-Catalyzed Synthesis of Diaryl Difluoromethanes from Aryl Halides and Aryldifluoromethyl Trimethylsilanes
1212
Palladium-Catalyzed Cross-Coupling of Silicon-Masked Diazenyl Anions and (Hetero)Aryl Halides
1213
Cu-Catalyzed Borylallylation of in situ Generated Imines – ­Lewis Base Additive Prevents Direct C–N Coupling
1214
Photoinduced Ring Opening of Cycloalkanols under Dual Organophotoredox and Copper Catalysis
1215
Nickel-Catalyzed Dearomative Arylcyanation of Indoles
1216
Palladium-Catalyzed, Directing Group-Enabled Perfluoroselenolation of Vinylic C–H Bonds
1217
Let’s Do The Twist: Atroposelective Suzuki–Miyaura Cross-Coupling to Access Axially Chiral Biphenols
1218
Nickel-Catalyzed Enantioselective Tandem Aza-Heck Cyclization and Cross-Coupling with Alkyl Iodides
1219
Modular Palladium-Catalyzed Synthesis of Highly Conjugated Benzophosphole Derivatives
1220
A Bench-Stable Bismuth(III) Precursor Promotes theα-Arylation of 1,3-Diketones with Arylboronic Acids
1221
The Hirao Reaction: Palladium-Catalyzed Cross-Coupling of Dialkyl Phosphites with Aryl Halides
1222
Copper-Catalyzed Conjugate Borylation of Enones

Polymer-Supported Synthesis

z1223
All PDFs of this category
1223
Aerobic Oxidation of Alcohols and Sulfides on Todorokite-Type Manganese Oxide Nanoparticles
1224
Michael Addition of Aldehydes to Nitrostyrenes on a Tetrahydropyran-Based Dipeptide Catalyst
1225
Amination and Trifluoroethylation of Fullerenes Promoted by Subphthalocyanine Capsules
1226
Diastereoselective Hydrogenation of Arenes and Pyridines Promoted by a Ru-Phenanthroline Catalyst
1227
Oxidation of Benzylic C–H Bonds with a Single-Atom-Like Zinc Catalyst
1228
Preparation of α-Hydroxy Carboxylic Acids by Carboxylation of Aldehydes on a Nickel(II) Catalyst
1229
Synthesis of 3,4-Dihydro-2H-Pyrroles by a Nickel-Catalyzed Hydrogenative Cyclization
1230
Heterogeneous Photocatalytic Synthesis of Functionalized Dihydropyrazoles from Hydrazones
1231
Photocatalytic Hydrogenation of Olefins and Nitro-benzenes with Al–H2O on Pd-Doped Carbon Nitride
1232
Asymmetric Alkylation of α,β-Unsaturated Ketones or Imines on a Polymeric Copper Catalyst
1233
Nanohybrid Photocatalyst for the Synthesis of Aryl Carbonyl Compounds and Benzimidazoles

Organo- and Biocatalysis

z1235
All PDFs of this category
1235
Thioxanthone-Catalyzed Single-Step Synthesis of β- and γ-Amino Acid Derivatives
1236
Supramolecular Capsule Emulates Enzymatic Proton-Wire Mechanism in β-Selective O-Glycosylations
1237
Biocatalytic Double- and Triple-Cascades Permit Highly Stereoselective Syntheses of Cyclohexene Derivatives
1238
Photocatalytic Functionalization of Nonactivated C(sp3)–H Bonds
1239
Photoredox-Catalyzed Imino Alkylation of Electronically Diverse Alkenes with Bifunctional Oxime Esters
1240
N-Arylphenothiazine-Catalyzed Cross-Coupling of Allyl Bromides with Arylboronic Acids
1241
Organocatalytic Construction of Heterobiaryl Atropisomers via Vinylidene–Quinone Methides
1242
Disulfide Reagent for Catalytic Asymmetric α-Alkylsulfenylation of Carbonyl Compounds
1243
Organocatalytic On-Water System for the Synthesis of α-Tertiary Amines
1244
Intermolecular Organosulfide-Catalyzed Difunctionalization of Allylic Sulfonamides
1245
Enzymatic Site-Selective and Atroposelective Bromination of 3-Aryl-4(3H)-Quinazolinones
1246
Organocatalytic Cationic Polymerization toward High-Molecular-Weight Poly(2,3-Dihydrofuran)

Innovative Drug Discovery and Development

z1247
All PDFs of this category
1247
Kinetic Target-Guided Synthesis of ERAP2 Inhibitors
1248
α-Synuclein Proaggregators via C–H Arylation
1249
A Non-Peptidic Protease Inhibitor for HIV Treatment
1250
Lomaiviticin A Monomer – Not as Cytotoxic as the Dimer
1251
Synthesis and Reevaluation of (+)- and (−)-Collybolide as kappa-Opioid Receptor Agonists
1252
Dual-Controlled Tumor Imaging using an Enzyme-Responsive and Photoactivated Probe
1253
Shortest Synthesis of Lysergol and its Binding to 5-HT1/2Receptors
1254
Dynamic Kinetic Resolution of Axially Chiral MRTX1719
1255
A Medicinal Chemist's Guide to Decarboxylative Cross-Couplings
1256
Atroposelective Annulations Afford Darobactin A
1257
Targeting KRAS G12R with α,β-Diketoamides
1258
Selective CYP11B1 Inhibitor Development via an Enantiomer Discrimination
1259
Application of Continuous Processing for a Scalable High-Temperature Racemization
1260
Design of a GPCR Antagonist from Agonist Scaffold
1261
A Candidate for Potential Treatment of Heart Failure with Preserved Ejection Fraction
1262
An Ene-reaction Ene-ables an α-Kainic Acid Synthesis

Peptide Chemistry

z1263
All PDFs of this category
1263
Palladium-Catalyzed C(sp3)–H Arylation of Cyclic Peptides
1264
C–H Alkylation for the Synthesis of Tetrasubstituted Amino Acid Derivatives
1265
Primary Amine–Thiourea-Catalyzed Enantioselective Alkylation of Cyclic Ketones
1266
Functionalization of Aspartic or Glutamic Acids through Photoinduced Decarboxylation
1267
Iridium-Catalyzed Photochemical [2+2]-Cycloaddition of Dehydroamino Acids with Styrenes
1268
Synthesis of α-Amino Acids by Enantioselective Carbene Insertion
1269
Potassium Fluoride-Mediated Deprotection of Fmoc-Amino Acid Esters: One-Pot Peptide Synthesis
1270
Chiral Calcium Phosphate-Catalyzed Amination of β-Keto Esters

Flow Chemistry

z1271
All PDFs of this category
1272
Synthesis of α-Aminoamides by a Photocatalytic Continuous-Flow Reaction
1273
Scalable Photoalkylation of Carbohydrates in Flow with a Sustainable Organocatalyst
1274
Hydrogen-Transfer Reaction Using Packed-Column Catalysts in Flow
1275
Photochemical Approach for the Synthesis of Tetrahydroimidazo[1,2-a]pyridine 1-Oxides